Document Detail

Metabolic syndrome and insulin resistance are associated with abnormal left ventricular diastolic function and structure independent of blood pressure and fasting plasma glucose level.
MedLine Citation:
PMID:  21392830     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Abnormal left ventricular (LV) structure and diastolic function are frequently detected in a variety of heart diseases, and insulin resistance has been suggested to be associated with LV diastolic dysfunction (LVDD). The aims of this study were to determine the association between LVDD or LV structure and metabolic syndrome (MetS) or insulin resistance, and whether or not the associations are independent of age, blood pressure, and plasma glucose level.
METHODS: A total of 1599 subjects (1161 men and 398 women), 25-83 years of age, who underwent medical health check-ups at two institutions, were enrolled. LV diastolic function and structure were assessed by echocardiographic evaluation, including tissue Doppler imaging (TDI).
RESULTS: The subjects with MetS had significant differences in the level of parameters reflecting cardiac structure and LV diastolic function compared to those without MetS, even after adjustment for age, gender, blood pressure, and fasting plasma glucose level (P<0.001). MetS was independently associated with an increased risk for LVDD (OR, 1.67; 95% CI, 1.18-2.37; P = 0.004). In addition, as the HOMA-IR value increased, the level of parameters reflecting cardiac structure and LVDD significantly increased and the E/A ratio significantly decreased (P<0.001). Furthermore, the LV mass, E/A ratio, and E/E' ratio were significantly different across the HOMA-IR quartiles, even after adjustment for other confounders.
CONCLUSIONS: MetS and insulin resistance are associated with abnormal LV diastolic function and structure independent of age, gender, blood pressure, and fasting plasma glucose level.
You-Cheol Hwang; Jae Hwan Jee; Mira Kang; Eun-Jung Rhee; Jidong Sung; Moon-Kyu Lee
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2011-03-10
Journal Detail:
Title:  International journal of cardiology     Volume:  159     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-14     Completed Date:  2013-06-06     Revised Date:  2013-10-16    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee East-West Neo Medical Center, Kyung Hee University School of Medicine, Seoul, Republic of Korea.
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MeSH Terms
Aged, 80 and over
Blood Glucose / metabolism*
Blood Pressure / physiology*
Fasting / blood
Hypertrophy, Left Ventricular / blood*,  epidemiology,  physiopathology
Insulin Resistance / physiology*
Metabolic Syndrome X / blood*,  epidemiology,  physiopathology
Middle Aged
Ventricular Dysfunction, Left / blood*,  epidemiology,  physiopathology
Reg. No./Substance:
0/Blood Glucose
Comment In:
Int J Cardiol. 2013 Jun 20;166(2):542   [PMID:  23103141 ]
Int J Cardiol. 2013 Sep 10;167(6):3037-8   [PMID:  23194785 ]

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