| Metabolic syndrome in bipolar disorder: a cross-sectional assessment of a Health Management Organization database. | |
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MedLine Citation:
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PMID: 18657245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the prevalence of metabolic syndrome (MS) in patients with bipolar disorder (BD) included in a Health Management Organization (HMO) database. METHODS: A cross-sectional analysis of the administrative claim database of Badalona Serveis Assistencials (BSA) was performed. All patients of either sex over 16 years of age and receiving treatment for BD for more than three weeks were included in the study group. The reference group comprised the rest of patients in the BSA database without BD. MS was defined according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III modified criteria and required fulfillment of at least three of the following five components: body mass index (BMI) >or=28.8 kg/m(2), triglycerides >or=150 mg/dL, high-density lipoprotein (HDL) cholesterol <40 mg/dL (males)/<50 mg/dL (females), blood pressure >or=130/85 mmHg, and fasting glucose >or=110 mg/dL. Descriptive statistics, bivariate analysis, and logistic regression models were applied. RESULTS: We identified 178 patients with BD out of 86,028 subjects (50.5% women; 45.5 +/- 17.8 years, mean +/- SD) included in the BSA database. MS prevalence was significantly higher in BD: 24.7% [95% confidence interval (CI): 18.6-31.7] versus 14.4% (CI: 14.2-14.7) with no statistically significant differences between genders; age-adjusted odds ratio (OR) = 1.65 (1.11-2.44, p = 0.013). All MS components were higher in the BD group, particularly BMI >28.8 kg/m(2) [33.1% (26.3-40.6) versus 17.9% (17.7-18.2), adjusted OR = 2.05 (1.46-2.87, p < 0.001)], high triglyceride levels [23.0% (17.1-29.9) versus 11.3% (11.1-11.5), adjusted OR = 2.09 (1.45-3.02, p < 0.001)], and low HDL cholesterol levels [54.5% (46.9-62.0) versus 29.4% (29.1-29.7), adjusted OR = 2.77 (2.02-3.80, p < 0.001)]. Furthermore, patients with BD showed a significantly higher frequency of obesity [41.4% (32.3-50.9) versus 27.1% (26.6-27.5); adjusted OR = 1.83 (1.24-2.68, p = 0.002)]. CONCLUSIONS: Compared with the general population managed by the BSA, the prevalence of MS was significantly higher in patients with BD, mainly due to a higher prevalence of obesity, high triglyceride levels, and low HDL cholesterol levels. These findings strongly support the development of health policies addressing this problem in BD patients. |
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Authors:
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Antoni Sicras; Javier Rejas; Ruth Navarro; Josep Serrat; Milagrosa Blanca |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bipolar disorders Volume: 10 ISSN: 1399-5618 ISO Abbreviation: Bipolar Disord Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-28 Completed Date: 2008-09-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883596 Medline TA: Bipolar Disord Country: Denmark |
Other Details:
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Languages: eng Pagination: 607-16 Citation Subset: IM |
Affiliation:
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Badalona Serveis Assistencials, Badalona, Barcelona, Spain. asicras@bsa.gs |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Antimanic Agents / adverse effects, therapeutic use Antipsychotic Agents / adverse effects, therapeutic use Bipolar Disorder / blood, epidemiology* Cholesterol, LDL / blood Comorbidity Cross-Sectional Studies Data Collection / statistics & numerical data Female Health Maintenance Organizations / statistics & numerical data* Humans Male Medical Records Systems, Computerized / statistics & numerical data Metabolic Syndrome X / blood, epidemiology* Middle Aged Obesity / blood, epidemiology Risk Factors Sex Factors Spain Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Antimanic Agents; 0/Antipsychotic Agents; 0/Cholesterol, LDL; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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