| Metabolic syndrome, hormones, and maintenance of T cells during aging. | |
| | |
MedLine Citation:
|
PMID: 20591642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although the phenotype of T-cell senescence has been extensively investigated, few studies have analyzed the factors that promote the generation and maintenance of naïve and memory T cells that exist throughout the lifespan of the individuals. Unlike senescent T cells, naïve and memory T cells are able to participate in useful immune responses as well as respond to new activation. Hormones such as leptin, ghrelin, insulin-like growth factor 1, IGFBP3, and cytokines, including IL-7, regulate both thymopoiesis and maintenance of naïve T cells in the periphery. Although chronic viruses such as cytomegalovirus (CMV) are thought to drive T-cell senescence, other microbes may be important for the maintenance of nonsenescent T cells. Microbiota of the gut can induce metabolic syndrome as well as modulate T-cell development into specific subpopulations of effector cells. Finally, T-cell generation, maintenance, and apoptosis depend upon pathways of energy utilization within the T cells, which parallel those that regulate overall metabolism. Therefore, better understanding of metabolic syndrome, T-cell metabolism, hormones, and microbiota may lead to new insights into the maintenance of proper immune responses in old age. |
| | |
Authors:
|
Hui-Chen Hsu; John D Mountz |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-06-28 |
Journal Detail:
|
Title: Current opinion in immunology Volume: 22 ISSN: 1879-0372 ISO Abbreviation: Curr. Opin. Immunol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-16 Completed Date: 2010-11-12 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8900118 Medline TA: Curr Opin Immunol Country: England |
Other Details:
|
Languages: eng Pagination: 541-8 Citation Subset: IM |
Copyright Information:
|
Published by Elsevier Ltd. |
Affiliation:
|
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Cell Aging / immunology Hormones / physiology* Humans Metabolic Syndrome X / immunology* T-Lymphocytes / immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 AG022064/AG/NIA NIH HHS; P01 AG022064-01A1/AG/NIA NIH HHS; P01 AG022064-02/AG/NIA NIH HHS; P01 AG022064-03/AG/NIA NIH HHS; P01 AG022064-04/AG/NIA NIH HHS; P01 AG022064-05/AG/NIA NIH HHS; P01 AG022064-06/AG/NIA NIH HHS; P01 AG022064-06S1/AG/NIA NIH HHS; R01 AG011653-05/AG/NIA NIH HHS; R01 AG011653-05S1/AG/NIA NIH HHS; R01 AG011653-06A2/AG/NIA NIH HHS; R01 AG011653-06A2S1/AG/NIA NIH HHS; R01 AG011653-07/AG/NIA NIH HHS; R01 AG011653-08/AG/NIA NIH HHS; R01 AG011653-09/AG/NIA NIH HHS; R01 AG011653-10/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Hormones |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relevance of human anatomy in daily clinical practice.
Next Document: Influence of oxygen flow rate on reaction rate of organic matter in leachate from aerated waste laye...