| Metabolic syndrome: clinical concept and molecular basis. | |
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MedLine Citation:
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PMID: 17852038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolic syndrome is a cluster of insulin resistance, elevated blood pressure, and atherogenic dyslipidemia and is a common basis of cardiovascular diseases (CVD). Although the precise mechanism remains to be elucidated, a practical definition is needed. A worldwide definition that considers increased waist circumference as an essential component has been settled. Visceral fat locates upstream of the liver. Free fatty acids and glycerol derived from visceral fat reach the liver and stimulate lipoprotein synthesis and gluconeogenesis, respectively. The adipose tissue produces a variety of bioactive substances conceptualized as 'adipocytokines'. Overproduction of plasminogen activator inhibitor-1 and tumor necrosis factor- seems to relate to the thrombotic and inflammatory tendency. On the other hand, adiponectin, which has antiatherogenic and antidiabetic activities, is reduced in subjects with metabolic syndrome. In Japan, the waist circumference criterion based on visceral fat accumulation has been adopted. The concept of this syndrome has been widely publicized, and health promotion programs based on the concept have commenced in various areas of the country. Such 'Adipo-Do-It' movement is an incentive to encourage physical exercise to reduce visceral fat and is a big challenge to prevent life-style-related diseases and CVD. |
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Authors:
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Tohru Funahashi; Yuji Matsuzawa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of medicine Volume: 39 ISSN: 0785-3890 ISO Abbreviation: Ann. Med. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-03 Completed Date: 2008-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8906388 Medline TA: Ann Med Country: Sweden |
Other Details:
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Languages: eng Pagination: 482-94 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan. tohru@imed2.med.osaka-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipokines
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physiology* Humans Intra-Abdominal Fat / physiology Metabolic Syndrome X / etiology*, prevention & control Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Adipokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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