| Metabolic syndrome is associated with gastroesophageal reflux disease based on a 24-hour ambulatory pH monitoring. | |
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MedLine Citation:
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PMID: 20946134 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Several studies have focused on the relationship between metabolic syndrome and gastroesophageal reflux disease (GERD). They were based on GERD complications, whereas little is known about the association between metabolic syndrome and objectively measured esophageal acid exposure. The aim of our study was to assess the relationship between metabolic syndrome and GERD based on a 24-hour pH testing. It was a cross-sectional study including 100 consecutive patients who underwent a 24-hour pH-metry monitoring and were assessed for the five metabolic syndrome components as well as for body mass index (BMI). Among the 100 patients, 54 had a pathological acid GERD. The 46 GERD-free patients represented control group. Sex distribution was comparable between both groups but GERD patients were older than controls (44.59 vs. 37.63 years, P= 0.006) and more often obese or with overweight (83.3 vs. 60.9%, P= 0.01). Frequency of metabolic syndrome as a whole entity was higher among patients with GERD than those without GERD (50 vs. 19.56%; P= 0.002) with a crude odds ratio of 4.11 (95% confidence interval: 1.66-10.14). Multivariate regression analysis showed that metabolic syndrome as well as an age ≥30 years were independent factors associated to GERD but not BMI and sex. Abnormal waist circumference and fasting glucose level ≥100 mg/L were the only independent factors among the five components of metabolic syndrome. Metabolic syndrome but not BMI was an independent factor associated to GERD. These results confirm the hypothesis that central obesity is associated to GERD. |
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Authors:
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L Kallel; N Bibani; M Fekih; S Matri; S Karoui; N B Mustapha; M Serghini; L Zouiten; M Feki; B Zouari; J Boubaker; N Kaabachi; A Filali |
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Publication Detail:
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Type: Journal Article Date: 2010-10-13 |
Journal Detail:
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Title: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E Volume: 24 ISSN: 1442-2050 ISO Abbreviation: Dis. Esophagus Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809160 Medline TA: Dis Esophagus Country: Australia |
Other Details:
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Languages: eng Pagination: 153-9 Citation Subset: IM |
Copyright Information:
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© 2010 Copyright the Authors. Journal compilation © 2010, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus. |
Affiliation:
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Department of Gastroenterology A Biochemistry Laboratory Rabta Hospital Laboratory of Statistics, Medical University of Tunis, Tunis, Tunisia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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