| Metabolic syndrome and alanine aminotransferase: a global perspective from the NAVIGATOR screening population. | |
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MedLine Citation:
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PMID: 20002471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Non-alcoholic fatty liver disease (NAFLD) is associated with features of the metabolic syndrome (MetS) and may be an expression of the syndrome within the liver. Using screening data from the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) study (n = 42 149), we examined whether alanine aminotransferase (ALT), a biomarker for NAFLD, clustered with features of MetS and whether the clusters differed across global geographic regions. METHODS: Exploratory factor analysis using principle components analysis was applied to data drawn from the NAVIGATOR screening population (n = 41 111). Demographic data, anthropomorphic measurements and blood pressure (BP) collected during the screening visit, as well as blood samples analysed for ALT, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and fasting and 2-h glucose measures after an oral glucose tolerance test were used for our analysis. RESULTS: Two factors, interpreted as lipid (Factor 1), and BP/obesity (Factor 2) were identified, explaining approximately 50% of the variance in the overall population. Similar patterns of aggregation were reproducible across all geographic regions except Asia, where fasting glucose loaded more consistently on Factor 1. ALT loaded with mean arterial pressure, fasting glucose and waist circumference except in Asia, where it loaded only with mean arterial pressure and waist circumference. CONCLUSIONS: ALT aggregated with components of MetS, and the pattern of aggregation of ALT with other features of MetS was similar across regions except Asia, possibly indicating a different pathophysiology for NAFLD in Asia. Predictive models of NAFLD may need to be adjusted for regional and ethnic differences. |
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Authors:
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M A Bethel; P Deedwania; N S Levitt; O Schmitz; A Huntsman-Labed; R M Califf; S M Haffner; P Diem; |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 26 ISSN: 1464-5491 ISO Abbreviation: Diabet. Med. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: England |
Other Details:
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Languages: eng Pagination: 1204-11 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC, USA. angelyn.bethel@dtu.ox.ac.uk |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00097786 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alanine Transaminase / blood*, diagnostic use Biological Markers Blood Pressure Cholesterol / blood Factor Analysis, Statistical Fatty Liver / complications, metabolism Female Glucose Intolerance / complications Glucose Tolerance Test Humans Lipoproteins / blood Male Metabolic Syndrome X / blood*, physiopathology* Middle Aged Obesity / physiopathology Predictive Value of Tests Triglycerides / blood World Health |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipoproteins; 0/Triglycerides; 57-88-5/Cholesterol; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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