Document Detail


Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease.
MedLine Citation:
PMID:  16875914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The prognosis associated with metabolic syndrome and high-sensitivity C-reactive protein (hs-CRP) in patients with stable coronary artery disease has not been well established. METHODS: The WIZARD study was to determine the effects of 12 weeks of antibiotic therapy on coronary heart disease events in patients with stable coronary artery disease and known Chlamydia pneumoniae exposure. Baseline metabolic risk factors were available for 3319 patients enrolled from 1997 to 1998. The primary outcome was the first occurrence of death, recurrent myocardial infarction, coronary revascularization procedure, or hospitalization for angina. RESULTS: Of the 3319 subjects, 825 patients experienced the primary outcome during the mean follow-up of 37 months. For the composite outcome, there was an increased hazard ratio (HR) for metabolic syndrome (HR 1.40, 95% CI 1.22-1.61) (unadjusted) and for hs-CRP (HR 1.60, 95% CI 1.38-1.85) (unadjusted). Both the metabolic syndrome and hs-CRP indicated, in a multivariable model including age and sex, an increased HR for the primary outcome (metabolic syndrome: HR 1.33, 95% CI 1.15-1.53; hs-CRP: HR 1.52, 95% CI 1.30-1.76). CONCLUSIONS: Although related, the presence of the metabolic syndrome and increased levels of hs-CRP were associated with increased risk of adverse cardiovascular outcomes.
Authors:
David Aguilar; Marian R Fisher; Christopher M O'Connor; Michael W Dunne; Joseph B Muhlestein; Louis Yao; Sandeep Gupta; Rebecca J Benner; Thomas D Cook; Dearborn Edwards; Marc A Pfeffer;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  152     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  298-304     Citation Subset:  AIM; IM    
Affiliation:
Cardiology Division, Baylor College of Medicine, Houston, TX 77030, USA. daguilar@bcm.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
C-Reactive Protein / analysis*
Cholesterol, HDL / blood
Coronary Disease / blood*,  epidemiology*
Diabetes Mellitus / epidemiology
Female
Humans
Hypertension / blood,  epidemiology
Male
Metabolic Syndrome X / blood*,  epidemiology*
Middle Aged
Multivariate Analysis
Prevalence
Prognosis
Risk Assessment
Risk Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Triglycerides; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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