Document Detail


"Metabolic switch" for desert survival.
MedLine Citation:
PMID:  7991624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Food, like water, is in short supply in the desert. We report a specialized mechanism used by a desert mouse for surviving prolonged food shortages. The key element of this adaptation is a large reduction in resting metabolism. After about 2 weeks of restricted food intake (50% of normal), the desert mouse "switched down" its resting metabolism and was able to survive and maintain its weight indefinitely on these limited rations. When food was again freely available, resting metabolism "switched up," returning to normal levels in a single day. The reduced metabolism occurred without a decrease in body temperature or in levels of activity. In marked contrast, metabolism of the laboratory white mouse increased during food restriction, and the experiments had to be terminated to avoid starvation. We think this "metabolic switch" is common among desert mammals. It may be an amplification of a general metabolic response for coping with food scarcity common to all mammals, including humans.
Authors:
J R Merkt; C R Taylor
Related Documents :
8858374 - Influence of feeding pattern on thyroid hormones in long-term food-restricted rats.
8254284 - Interactions between growth hormone and nutrition in hypophysectomized rats: body compo...
3167764 - Inhibition of the development of tumors or leukemia in mice and rats after reduction of...
1904964 - Change with age of uv absorbance and fluorescence of collagen and accumulation of epsil...
9027524 - Lower consumption of wine and fish as a possible explanation for higher ischaemic heart...
12820994 - Comparison of biomarker and pathological responses in flounder (platichthys flesus l.) ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  91     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-01-11     Completed Date:  1995-01-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  12313-6     Citation Subset:  IM    
Affiliation:
Harvard University, Museum of Comparative Zoology, Bedford, MA 01730.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Animals
Basal Metabolism*
Body Temperature
Desert Climate
Female
Food Supply
Male
Mice / physiology
Muridae / physiology*
Oxygen Consumption
Species Specificity
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injury.
Next Document:  Modulator factor-binding sequence of the sea urchin early histone H2A promoter acts as an enhancer e...