| Metabolic support during coronary reperfusion. | |
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MedLine Citation:
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PMID: 3300232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The limitation of infarct size by thrombolysis could potentially be improved by an early metabolic intervention. We therefore evaluated the effects of a 48-hour infusion of glucose-insulin-potassium (GIK) in patients with anterior infarctions. Seventeen patients were randomized to receive intravenous GIK (n = 10) or placebo (n = 7). All patients additionally received streptokinase. Changes in left ventricular function were assessed by comparing the global ejection fractions and the regional infarct area ejection fractions of the first ventriculogram with the 10-day second ventriculogram. There was a significantly greater improvement in the global ejection fraction of patients receiving GIK (increases 0.07 +/- 0.04) than in those randomized to placebo (decreases 0.08 +/- 0.04) (p less than 0.02). There was also a much greater improvement in the area ejection fractions of the group receiving GIK vs the group receiving placebo in the anterolateral (increases 0.24 +/- 0.07 vs decreases 0.02 +/- 0.04 [p less than 0.02]) and diaphragmatic (increases 0.08 +/- 0.08 vs decreases 0.17 +/- 0.05 [p less than 0.005]) segments. Thus in patients with anterior infarctions receiving streptokinase, GIK improves ventricular function and reduces the size of the segmental wall motion abnormality. |
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Authors:
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L F Satler; C E Green; K M Kent; R S Pallas; D L Pearle; C E Rackley |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American heart journal Volume: 114 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-07-30 Completed Date: 1987-07-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 54-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Clinical Trials as Topic Coronary Circulation Coronary Thrombosis / drug therapy Double-Blind Method Female Glucose / administration & dosage* Humans Infusions, Intravenous Insulin / administration & dosage* Male Middle Aged Myocardial Contraction / drug effects Myocardial Infarction / drug therapy*, physiopathology Perfusion / methods* Potassium / administration & dosage* Random Allocation Streptokinase / therapeutic use Stroke Volume |
| Chemical | |
Reg. No./Substance:
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0/glucose-insulin-potassium cardioplegic solution; 11061-68-0/Insulin; 50-99-7/Glucose; 7440-09-7/Potassium; EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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