Document Detail

Metabolic support during coronary reperfusion.
MedLine Citation:
PMID:  3300232     Owner:  NLM     Status:  MEDLINE    
The limitation of infarct size by thrombolysis could potentially be improved by an early metabolic intervention. We therefore evaluated the effects of a 48-hour infusion of glucose-insulin-potassium (GIK) in patients with anterior infarctions. Seventeen patients were randomized to receive intravenous GIK (n = 10) or placebo (n = 7). All patients additionally received streptokinase. Changes in left ventricular function were assessed by comparing the global ejection fractions and the regional infarct area ejection fractions of the first ventriculogram with the 10-day second ventriculogram. There was a significantly greater improvement in the global ejection fraction of patients receiving GIK (increases 0.07 +/- 0.04) than in those randomized to placebo (decreases 0.08 +/- 0.04) (p less than 0.02). There was also a much greater improvement in the area ejection fractions of the group receiving GIK vs the group receiving placebo in the anterolateral (increases 0.24 +/- 0.07 vs decreases 0.02 +/- 0.04 [p less than 0.02]) and diaphragmatic (increases 0.08 +/- 0.08 vs decreases 0.17 +/- 0.05 [p less than 0.005]) segments. Thus in patients with anterior infarctions receiving streptokinase, GIK improves ventricular function and reduces the size of the segmental wall motion abnormality.
L F Satler; C E Green; K M Kent; R S Pallas; D L Pearle; C E Rackley
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American heart journal     Volume:  114     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-07-30     Completed Date:  1987-07-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  54-8     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Coronary Circulation
Coronary Thrombosis / drug therapy
Double-Blind Method
Glucose / administration & dosage*
Infusions, Intravenous
Insulin / administration & dosage*
Middle Aged
Myocardial Contraction / drug effects
Myocardial Infarction / drug therapy*,  physiopathology
Perfusion / methods*
Potassium / administration & dosage*
Random Allocation
Streptokinase / therapeutic use
Stroke Volume
Reg. No./Substance:
0/glucose-insulin-potassium cardioplegic solution; 11061-68-0/Insulin; 50-99-7/Glucose; 7440-09-7/Potassium; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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