Document Detail


Metabolic substrates, muscle fibre composition and fibre size in late walking and normal children.
MedLine Citation:
PMID:  421694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 10 children with delayed walking, muscle specimens were obtained by needle biopsy from the vastus lateralis muscle for determination of ATP, creatine phosphate (CP), glycogen and lactate concentration, as well as fibre composition and fibre size. The values obtained are compared with corresponding results for a control group of 25 children aged 2 months--11 years. Details of the control series are given and its validity as a reference group is discussed. Six children (group I) who showed minor gross motor delay but otherwise normal development at follow-up were found to have lowered ATP, CP and glycogen concentrations, compared to 4 children (group II) who had general developmental delay, and to the control group. The children in group I were shown to have smaller fibre size and a greater difference between type 1 and 2 fibres than the children in group II and in the control group. No differences in the concentrations of metabolic substrates or the morphometric values could be detected between group II and the control group.
Authors:
A Lundberg; B O Eriksson; G Mellgren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  130     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-05-16     Completed Date:  1979-05-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  79-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / analysis
Age Factors
Child
Child, Preschool
Glycogen / analysis
Humans
Infant
Lactates / analysis
Motor Skills*
Muscles / analysis*
Phosphocreatine / analysis
Time Factors
Chemical
Reg. No./Substance:
0/Lactates; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 9005-79-2/Glycogen

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