Document Detail


Metabolic studies on retinoic acid in the rat.
MedLine Citation:
PMID:  4330965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nature of metabolites in the urine arising from differentially labelled retinoic acid was investigated after injection of physiological doses into retinol-deficient rats. Distribution of radioactivity after partition of urine into ether-soluble, acidic and water-soluble fractions revealed that there were at least six metabolites in urine. Of these, the major metabolite(s) was one lacking both C-14 and C-15 of retinoic acid. Enzymic or alkaline hydrolysis of acidic and water-soluble fractions did not release any retinoic acid, thus indicating that retinoyl beta-glucuronide was not present in urine in significant amounts.
Authors:
P R Sundaresan; H N Bhagavan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  122     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1971 Mar 
Date Detail:
Created Date:  1972-02-11     Completed Date:  1972-02-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Isotopes
Carotenoids / metabolism*,  urine
Chromatography
Ethyl Ethers
Glucuronidase
Hydrochloric Acid
Hydrolysis
Male
Rats
Silicon Dioxide
Solubility
Vitamin A Deficiency / metabolism
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Ethyl Ethers; 36-88-4/Carotenoids; 7631-86-9/Silicon Dioxide; 7647-01-0/Hydrochloric Acid; EC 3.2.1.31/Glucuronidase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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