| Metabolic studies of a podophyllotoxin derivative (VP16) in the isolated perfused liver. | |
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MedLine Citation:
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PMID: 4024669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolism of VP16 was studied in isolated perfused rat liver. The rate of elimination into the medium and excretion in bile were determined by h.p.l.c. with u.v. detection. With high VP16 concentrations (180 micrograms/ml medium), the elimination half-life of the compound was prolonged markedly (156 v. 45 min for lower doses), the percentage recovered in bile was more than halved and drug accumulation in the hepatic tissue was three times greater. These findings indicate saturation of metabolism and of biliary elimination during high-dose treatment. The presence of glucuronides in the bile of VP16 perfused livers indicates that VP16 undergoes conjugation with glucuronic acid. Formation of picro isomer of VP16 in the liver also occurs. |
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Authors:
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T Colombo; M D'Incalci; M G Donelli; I Bartosek; E Benfenati; P Farina; A Guaitani |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 15 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-09-25 Completed Date: 1985-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 343-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / analysis Etoposide / metabolism* Isomerism Kinetics Liver / metabolism* Male Mass Spectrometry Perfusion Podophyllotoxin / analogs & derivatives* Rats Rats, Inbred Strains Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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33419-42-0/Etoposide; 518-28-5/Podophyllotoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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