Document Detail


Metabolic studies in vivo with arylamines.
MedLine Citation:
PMID:  7341987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metabolic experiments have furnished leads on both the detoxification and activation pathways for aromatic amines. These consist largely of C- and N-hydroxylation, followed by conjugation with glucuronic or sulfuric acid, although other mechanisms may be involved. Current emphasis is on the N-hydroxylated derivatives as a precursor to the activated carcinogen. Metabolic patterns have furnished leads in some cases to account for the differences in susceptibility of various species to the carcinogenic aromatic amines, but discrepancies also occur.
Authors:
E K Weisburger
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  National Cancer Institute monograph     Volume:  -     ISSN:  0083-1921     ISO Abbreviation:  Natl Cancer Inst Monogr     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0216026     Medline TA:  Natl Cancer Inst Monogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  95-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
2-Acetylaminofluorene / metabolism
2-Naphthylamine / metabolism
Amines / metabolism*
Animals
Biotransformation
Carcinogens / metabolism*
Humans
Species Specificity
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Amines; 0/Carcinogens; 53-96-3/2-Acetylaminofluorene; 91-59-8/2-Naphthylamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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