| Metabolic studies in vivo with arylamines. | |
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MedLine Citation:
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PMID: 7341987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabolic experiments have furnished leads on both the detoxification and activation pathways for aromatic amines. These consist largely of C- and N-hydroxylation, followed by conjugation with glucuronic or sulfuric acid, although other mechanisms may be involved. Current emphasis is on the N-hydroxylated derivatives as a precursor to the activated carcinogen. Metabolic patterns have furnished leads in some cases to account for the differences in susceptibility of various species to the carcinogenic aromatic amines, but discrepancies also occur. |
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Authors:
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E K Weisburger |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: National Cancer Institute monograph Volume: - ISSN: 0083-1921 ISO Abbreviation: Natl Cancer Inst Monogr Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-07-08 Completed Date: 1982-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0216026 Medline TA: Natl Cancer Inst Monogr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 95-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Acetylaminofluorene
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metabolism 2-Naphthylamine / metabolism Amines / metabolism* Animals Biotransformation Carcinogens / metabolism* Humans Species Specificity Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Carcinogens; 53-96-3/2-Acetylaminofluorene; 91-59-8/2-Naphthylamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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