Document Detail


Metabolic and structural recovery of left ventricular canine myocardium from regional complete ischemia.
MedLine Citation:
PMID:  1157819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The capacity for recovery of the normothermic left ventricular myocardium from a regional complete ischemia (RCI) was investigated using changes in the myocardial metabolic status (ATP, ADP, AMP, creatine phosphate (CrP), free creatine, glycogen, glucose, lactate) and alterations of the morphology as parameters. In dogs, an area of the anterior wall of the left ventricular myocardium was temporarily deprived completely of its blood supply by 5--7 overlapping ligatures extending into the heart cavity. The metabolites of the adenylic acid-CrP system returned to normal tissue levels after 30 and 60 min of RCI within 14 and 35 days of recovery, respectively; restoration averaged 82% after 100 min, 74% after 140 min, and 38% after 180 min of RCI after 5 weeks of recovery. At the same time glycogen amounted to 163% after 100 min, 114% min, and 65% after 180 min of RCI. The biochemical data correlated well with the structural changes in the affected myocardium, especially with the amount of de- and regenerating heart muscle cells. These obviously were functionally defect and were not comparable with normal structured and functioning heart muscle cells.
Authors:
W Isselhard; K L Lauterjung; J Witte; T Ban; G Hübner; O Giersberg; E Heugel; H J Hirt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  7     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1975  
Date Detail:
Created Date:  1975-11-22     Completed Date:  1975-11-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  136-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / metabolism
Adenosine Monophosphate / metabolism
Adenosine Triphosphate / metabolism
Animals
Cell Nucleus / ultrastructure
Collagen
Coronary Disease / metabolism*
Creatine / metabolism
Dogs
Female
Glucose / metabolism
Glycogen / metabolism
Heart / physiology
Heart Ventricles / metabolism
Lactates / metabolism
Ligation
Male
Mitochondria, Muscle / ultrastructure
Myocardium / metabolism*,  ultrastructure
Myofibrils / ultrastructure
Phosphocreatine / metabolism
Time Factors
Ventricular Function
Chemical
Reg. No./Substance:
0/Lactates; 50-99-7/Glucose; 56-65-5/Adenosine Triphosphate; 57-00-1/Creatine; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 67-07-2/Phosphocreatine; 9005-79-2/Glycogen; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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