|Metabolic and structural recovery of left ventricular canine myocardium from regional complete ischemia.|
|PMID: 1157819 Owner: NLM Status: MEDLINE|
|The capacity for recovery of the normothermic left ventricular myocardium from a regional complete ischemia (RCI) was investigated using changes in the myocardial metabolic status (ATP, ADP, AMP, creatine phosphate (CrP), free creatine, glycogen, glucose, lactate) and alterations of the morphology as parameters. In dogs, an area of the anterior wall of the left ventricular myocardium was temporarily deprived completely of its blood supply by 5--7 overlapping ligatures extending into the heart cavity. The metabolites of the adenylic acid-CrP system returned to normal tissue levels after 30 and 60 min of RCI within 14 and 35 days of recovery, respectively; restoration averaged 82% after 100 min, 74% after 140 min, and 38% after 180 min of RCI after 5 weeks of recovery. At the same time glycogen amounted to 163% after 100 min, 114% min, and 65% after 180 min of RCI. The biochemical data correlated well with the structural changes in the affected myocardium, especially with the amount of de- and regenerating heart muscle cells. These obviously were functionally defect and were not comparable with normal structured and functioning heart muscle cells.|
|W Isselhard; K L Lauterjung; J Witte; T Ban; G Hübner; O Giersberg; E Heugel; H J Hirt|
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|Type: Journal Article|
|Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 7 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1975|
|Created Date: 1975-11-22 Completed Date: 1975-11-22 Revised Date: 2008-11-21|
Medline Journal Info:
|Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND|
|Languages: eng Pagination: 136-55 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Adenosine Monophosphate / metabolism
Adenosine Triphosphate / metabolism
Cell Nucleus / ultrastructure
Coronary Disease / metabolism*
Creatine / metabolism
Glucose / metabolism
Glycogen / metabolism
Heart / physiology
Heart Ventricles / metabolism
Lactates / metabolism
Mitochondria, Muscle / ultrastructure
Myocardium / metabolism*, ultrastructure
Myofibrils / ultrastructure
Phosphocreatine / metabolism
|0/Lactates; 50-99-7/Glucose; 56-65-5/Adenosine Triphosphate; 57-00-1/Creatine; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate; 67-07-2/Phosphocreatine; 9005-79-2/Glycogen; 9007-34-5/Collagen|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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