| Metabolic sequelae of β-blocker therapy: weighing in on the obesity epidemic? | |
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MedLine Citation:
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PMID: 21304487 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background:Sympathetic activation is an important metabolic adaptation limiting weight gain. Propensity of weight gain associated with β-blocker therapy in the obese modern population is unknown.Objective:To determine whether chronic β-blocker therapy reduces energy expenditure (EE) and increases body weight.Methods:We undertook (i) a mechanistic study comparing EE, diet-induced thermogenesis and habitual activity between healthy volunteers (n=11) with uncomplicated hypertension treated with a β-blocker and anthropometrically matched controls (n=19) and (ii) three cross-sectional studies comparing body weight, body mass index (BMI) and waist circumference between β-blocker treated and untreated patients from ambulatory patients attending (a) diabetes outpatient clinic (n=214), (b) hypertension outpatient (n=84) and (c) participants in a multi-centre type 2 diabetes trial (ADVANCE) (n=11140).Results:Among weight-matched β-blocker users, diet-induced thermogenesis, fat oxidation rate and weekly habitual activity were lower by 50% (P<0.01), 32% (P=0.04) and 30% (P<0.01), respectively, compared with controls. In β-blocker treated patients, the adjusted mean body weight was 9.2±1.2 kg (P=0.0002) higher among those attending the diabetes clinic, 17.2±3.2 kg (P=0.004) higher among those attending the hypertension clinic and 5.2±0.7 kg (P=0.0003) higher at baseline among participants in the ADVANCE trial compared with patients not treated with β-blockers. BMI displayed a similar difference.Conclusions:EE is reduced and body weight increased in chronic β-blocker users. We hypothesise that chronic β-blockade causes obesity by blunting EE.International Journal of Obesity advance online publication, 8 February 2011; doi:10.1038/ijo.2010.284. |
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Authors:
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P Lee; A-P Kengne; J R Greenfield; R O Day; J Chalmers; K K Y Ho |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-08 |
Journal Detail:
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Title: International journal of obesity (2005) Volume: - ISSN: 1476-5497 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Department of Endocrinology, St Vincent's Hospital, Sydney, New South Wales, Australia [2] Pituitary Research Unit, Garvan Institute of Medical Research, Sydney, New South Wales, Australia [3] Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. |
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