| Metabolic and reward feeding synchronises the rhythmic brain. | |
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MedLine Citation:
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PMID: 20563601 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Daily brain rhythmicity, which controls the sleep-wake cycle and neuroendocrine functions, is generated by an endogenous circadian timing system. Within the multi-oscillatory circadian network, a master clock is located in the suprachiasmatic nuclei of the hypothalamus, whose main synchroniser (Zeitgeber) is light. In contrast, imposed meal times and temporally restricted feeding are potent synchronisers for secondary clocks in peripheral organs such as the liver and in brain regions, although not for the suprachiasmatic nuclei. Even when animals are exposed to a light-dark cycle, timed calorie restriction (i.e. when only a hypocaloric diet is given every day) is a synchroniser powerful enough to modify the suprachiasmatic clockwork and increase the synchronising effects of light. A daily chocolate snack in animals fed ad libitum with chow diet entrains the suprachiasmatic clockwork only under the conditions of constant darkness and decreases the synchronising effects of light. Secondary clocks in the brain outside the suprachiasmatic nuclei are differentially influenced by meal timing. Circadian oscillations can either be highly sensitive to food-related metabolic or reward cues (i.e. their phase is shifted according to the timed meal schedule) in some structures or hardly affected by meal timing (palatable or not) in others. Furthermore, animals will manifest food-anticipatory activity prior to their expected meal time. Anticipation of a palatable or regular meal may rely on a network of brain clocks, involving metabolic and reward systems and the cerebellum. |
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Authors:
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Etienne Challet; Jorge Mendoza |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-20 |
Journal Detail:
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Title: Cell and tissue research Volume: 341 ISSN: 1432-0878 ISO Abbreviation: Cell Tissue Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: Germany |
Other Details:
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Languages: eng Pagination: 1-11 Citation Subset: IM |
Affiliation:
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Centre National de la Recherche Scientifique (CNRS), Institut Fédératif en Neurosciences de Strasbourg (IFR37), Associé à l'Université de Strasbourg, Strasbourg, France. challet@inci-cnrs.unistra.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Clocks / physiology Brain / physiology* Circadian Rhythm / physiology* Feeding Behavior / physiology* Reward* Suprachiasmatic Nucleus / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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