| Metabolic responses to tyramine and cold in young male Sprague-Dawley and Fischer 344 rats. | |
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MedLine Citation:
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PMID: 6696106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Significant differences in responses to intraperitoneally injected tyramine or cold exposure (-10 degrees C) were observed in young (3-4 mo) male Sprague-Dawley (S-D) and Fischer 344 (F344) rats cold-acclimated (CA) or non-cold-acclimated (non-CA). Non-CA S-D and F344 rats respond to tyramine by increased O2 uptake and elevation of colonic temperature, but, as we had reported previously, the optimal doses of tyramine required was significantly different for these two strains, i.e., 2 mg/kg for F344 vs. 20 mg/kg for S-D. The response to tyramine was significantly potentiated by cold acclimation in both strains of rats. Despite the different dosages of tyramine given to the animals, similar increases in O2 uptakes and colonic temperatures were observed. Differences between these two strains were also evident in their responses to a cold challenge (3 h, -10 degrees C). The ranking for cold tolerance (-10 degrees C) was as follows: CA F344 greater than non-CA F344 greater than CA S-D greater than non-CA S-D. These differences between the two strains suggest that interpretations regarding the response of rats to stressful conditions must be made with caution and appreciation of strain differences. |
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Authors:
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M Kiang-Ulrich; S M Horvath |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 246 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-03-16 Completed Date: 1984-03-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E141-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization* Aging Animals Body Temperature Cold Temperature* Colon / physiology Male Oxygen Consumption Rats Rats, Inbred F344 Rats, Inbred Strains / metabolism* Tyramine / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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AG-05204/AG/NIA NIH HHS; RRO 7099-15/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-67-2/Tyramine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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