Document Detail

Metabolic responses to tyramine and cold in young male Sprague-Dawley and Fischer 344 rats.
MedLine Citation:
PMID:  6696106     Owner:  NLM     Status:  MEDLINE    
Significant differences in responses to intraperitoneally injected tyramine or cold exposure (-10 degrees C) were observed in young (3-4 mo) male Sprague-Dawley (S-D) and Fischer 344 (F344) rats cold-acclimated (CA) or non-cold-acclimated (non-CA). Non-CA S-D and F344 rats respond to tyramine by increased O2 uptake and elevation of colonic temperature, but, as we had reported previously, the optimal doses of tyramine required was significantly different for these two strains, i.e., 2 mg/kg for F344 vs. 20 mg/kg for S-D. The response to tyramine was significantly potentiated by cold acclimation in both strains of rats. Despite the different dosages of tyramine given to the animals, similar increases in O2 uptakes and colonic temperatures were observed. Differences between these two strains were also evident in their responses to a cold challenge (3 h, -10 degrees C). The ranking for cold tolerance (-10 degrees C) was as follows: CA F344 greater than non-CA F344 greater than CA S-D greater than non-CA S-D. These differences between the two strains suggest that interpretations regarding the response of rats to stressful conditions must be made with caution and appreciation of strain differences.
M Kiang-Ulrich; S M Horvath
Related Documents :
3244046 - Effects of capsaicin and isothiocyanate on thermogenesis of interscapular brown adipose...
11417696 - Sympathetic nervous system activity in adipose tissues during pregnancy and lactation o...
14984316 - Triiodothyronine deiodinating activity in brown adipose tissue after short cold stimula...
7765856 - The effect of glucocorticoids on the activity of monoamine oxidase and superoxide dismu...
1516836 - Lead-induced lipid peroxidation and antioxidant defense components of developing chick ...
1336706 - Sexual differences in the stimulatory effects of bombesin on tuberoinfundibular dopamin...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  246     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-03-16     Completed Date:  1984-03-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E141-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Temperature
Cold Temperature*
Colon / physiology
Oxygen Consumption
Rats, Inbred F344
Rats, Inbred Strains / metabolism*
Tyramine / pharmacology*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of dietary preferences in the weaning pattern of the rat.
Next Document:  Effect of exogenous vasopressin on vasopressin release.