Document Detail


Metabolic responses to mid-pregnancy shearing that are associated with a selective increase in the birth weight of twin lambs.
MedLine Citation:
PMID:  10869859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have shown that shearing pregnant ewes at mid- or late-pregnancy is associated with an increase in lamb birth weight. The present study was designed to investigate metabolic responses that may underlie this response. Single- and twin-bearing ewes were either unshorn or shorn at mid-pregnancy (Day 69 of pregnancy; P69), and insulin, glucose and epinephrine challenges were conducted on P109-111 and P132-134. Shearing increased the birth weight of twin lambs by over 1 kg (P < 0.001) without having any effect on singleton birth weight. This response was associated with a 10-20% reduction in the insulin response to a glucose challenge (P < 0.05) without a change in glucose clearance following either glucose or insulin challenges. The lipolytic response to epinephrine challenge increased as pregnancy progressed, but was not associated with the increased birth weight of twin lambs born to shorn ewes. By late pregnancy, a 25% reduction in maternal IGF-I concentration and a two- to threefold increase in maternal IGFBP-1 concentration (P < 0. 05) associated with shearing were observed. The increase in lamb birth weight associated with mid-pregnancy shearing may have been associated with an increase in the non-insulin dependent uptake of glucose by the placental-fetal unit.
Authors:
D K Revell; S F Main; B H Breier; Y H Cottam; M Hennies; S N McCutcheon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Domestic animal endocrinology     Volume:  18     ISSN:  0739-7240     ISO Abbreviation:  Domest. Anim. Endocrinol.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-08-08     Completed Date:  2000-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505191     Medline TA:  Domest Anim Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-22     Citation Subset:  IM    
Affiliation:
Institute of Food, Nutrition and Human Health, Massey University, Palmerston North, New Zealand. dean.revell@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Area Under Curve
Birth Weight
Blood Glucose / analysis,  physiology
Cohort Studies
Colorimetry / veterinary
Eating
Epinephrine / pharmacology,  physiology*
Fatty Acids / blood
Female
Insulin / blood,  physiology,  secretion
Insulin-Like Growth Factor Binding Protein 1 / blood
Insulin-Like Growth Factor I / analysis
Linear Models
Male
Pregnancy
Pregnancy, Animal / physiology*
Radioimmunoassay / veterinary
Sheep / metabolism,  physiology*
Twins
Wool / physiology
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids; 0/Insulin-Like Growth Factor Binding Protein 1; 11061-68-0/Insulin; 51-43-4/Epinephrine; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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