Document Detail


Metabolic responses to change in disease activity during Tumor Necrosis Factor inhibition in patients with Rheumatoid Arthritis.
MedLine Citation:
PMID:  22574709     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: Assessment of disease activity in patients with rheumatoid arthritis (RA) is of importance in the evaluation of treatment. The most important measure of disease activity is the Disease Activity Score counted in 28 joints (DAS28). In this study we evaluated whether metabolic profiling could complement current measures of disease activity. Methods: Fifty-six patients, in two separate studies, were followed for two years after commencing anti-TNF therapy. DAS28 was assessed and metabolic profiles recorded at defined time points. Correlations between metabolic profile and DAS28 scores were analyzed using multivariate statistics. Results: The metabolic responses to lowering DAS28 scores varied in different patients, but could predict DAS28 scores at the individual and subgroup level models. The erythrocyte sedimentation rate (ESR) component in DAS28 was most correlated to the metabolite data, pointing to inflammation as the primary effect driving metabolic profile changes. Conclusions: Patients with RA had differing metabolic response to changes in DAS28 following anti-TNF therapy. This suggests that discovery of new metabolic biomarkers for disease activity will derive from studies at the individual and subgroup level. Increased inflammation, measured as ESR, was the main common effect seen in metabolic profiles from periods associated with high DAS28.
Authors:
Rasmus Madsen; Solbritt Rantapää-Dahlqvist; Torbjörn Lundstedt; Thomas Moritz; Johan Trygg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-10
Journal Detail:
Title:  Journal of proteome research     Volume:  -     ISSN:  1535-3907     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128775     Medline TA:  J Proteome Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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