Document Detail

Metabolic responses of dairy cows and heifers to various intravenous dosages of glucagon.
MedLine Citation:
PMID:  10386299     Owner:  NLM     Status:  MEDLINE    
To evaluate the ability of glucagon to improve carbohydrate status in dairy cows without an increase in blood lipids, glucagon was infused intravenously for 48 h into lactating cows and spayed heifers in three crossover experiments. During Experiment 1, glucagon (5 and 20 mg/d) was infused into four midlactation cows. Experiment 2 involved the infusion of 0, 2.5, 5.0, or 10 mg/d of glucagon into eight heifers; each heifer received two of the dosages. In Experiment 3, four early lactation cows were treated with 5 and 10 mg/d of glucagon. Glucagon consistently increased plasma glucose concentrations in a dose-dependent fashion throughout the 48-h periods. Plasma insulin was increased in a nondose-dependent manner by glucagon in Experiment 1. Plasma urea N was increased when glucagon was administered at 5 mg/d during Experiment 2 and tended to be decreased during Experiment 3. Nonesterified fatty acids in plasma were, in most cases, not affected; however, they were increased by glucagon at 10 mg/d during Experiment 2. Concentrations of beta-hydroxybutyrate were increased only by the 20-mg/d dosage. During Experiment 1, liver glycogen concentrations decreased by 2.1% (wet weight basis) for both dosages of glucagon, and concentrations of total lipid in the liver were increased by 0.6% (wet weight basis) by 20 mg/d of glucagon. Milk fat percentage was increased by glucagon, but milk volume and milk protein production were decreased during Experiment 1. Glucagon improved carbohydrate status over the 48-h periods in all experiments but did not increase plasma nonesterified fatty acids except at the 10-mg/d dosage in Experiment 2.
A R Hippen; P She; J W Young; D C Beitz; G L Lindberg; L F Richardson; R W Tucker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of dairy science     Volume:  82     ISSN:  0022-0302     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-07-16     Completed Date:  1999-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1128-38     Citation Subset:  IM    
Department of Animal Science, Iowa State University, Ames 50011-3150, USA.
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MeSH Terms
3-Hydroxybutyric Acid / blood
Blood Glucose / metabolism
Blood Urea Nitrogen
Cattle / metabolism*
Dose-Response Relationship, Drug
Fatty Acids, Nonesterified / blood
Glucagon / administration & dosage*
Glycogen / metabolism
Infusions, Intravenous
Insulin / blood
Lipid Metabolism
Liver / drug effects,  metabolism
Milk / chemistry
Milk Proteins / metabolism
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Milk Proteins; 11061-68-0/Insulin; 300-85-6/3-Hydroxybutyric Acid; 9005-79-2/Glycogen; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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