| Metabolic responses of dairy cows and heifers to various intravenous dosages of glucagon. | |
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MedLine Citation:
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PMID: 10386299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the ability of glucagon to improve carbohydrate status in dairy cows without an increase in blood lipids, glucagon was infused intravenously for 48 h into lactating cows and spayed heifers in three crossover experiments. During Experiment 1, glucagon (5 and 20 mg/d) was infused into four midlactation cows. Experiment 2 involved the infusion of 0, 2.5, 5.0, or 10 mg/d of glucagon into eight heifers; each heifer received two of the dosages. In Experiment 3, four early lactation cows were treated with 5 and 10 mg/d of glucagon. Glucagon consistently increased plasma glucose concentrations in a dose-dependent fashion throughout the 48-h periods. Plasma insulin was increased in a nondose-dependent manner by glucagon in Experiment 1. Plasma urea N was increased when glucagon was administered at 5 mg/d during Experiment 2 and tended to be decreased during Experiment 3. Nonesterified fatty acids in plasma were, in most cases, not affected; however, they were increased by glucagon at 10 mg/d during Experiment 2. Concentrations of beta-hydroxybutyrate were increased only by the 20-mg/d dosage. During Experiment 1, liver glycogen concentrations decreased by 2.1% (wet weight basis) for both dosages of glucagon, and concentrations of total lipid in the liver were increased by 0.6% (wet weight basis) by 20 mg/d of glucagon. Milk fat percentage was increased by glucagon, but milk volume and milk protein production were decreased during Experiment 1. Glucagon improved carbohydrate status over the 48-h periods in all experiments but did not increase plasma nonesterified fatty acids except at the 10-mg/d dosage in Experiment 2. |
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Authors:
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A R Hippen; P She; J W Young; D C Beitz; G L Lindberg; L F Richardson; R W Tucker |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of dairy science Volume: 82 ISSN: 0022-0302 ISO Abbreviation: J. Dairy Sci. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-07-16 Completed Date: 1999-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985126R Medline TA: J Dairy Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1128-38 Citation Subset: IM |
Affiliation:
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Department of Animal Science, Iowa State University, Ames 50011-3150, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid
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blood Animals Blood Glucose / metabolism Blood Urea Nitrogen Cattle / metabolism* Dose-Response Relationship, Drug Fatty Acids, Nonesterified / blood Female Glucagon / administration & dosage* Glycogen / metabolism Infusions, Intravenous Insulin / blood Lactation Lipid Metabolism Liver / drug effects, metabolism Milk / chemistry Milk Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Milk Proteins; 11061-68-0/Insulin; 300-85-6/3-Hydroxybutyric Acid; 9005-79-2/Glycogen; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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