Document Detail


Metabolic response to provision of mixed protein-carbohydrate supplementation during endurance exercise.
MedLine Citation:
PMID:  12500983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of substrates and hormones in response to ingestion of intact proteins during endurance exercise is unknown. This study characterized substrate and hormone responses to supplementation during endurance exercise. Nine male runners participated in 3 trials in which a non-fat (MILK), carbohydrate (CHO), or placebo (PLA) drink was consumed during a 2-hour treadmill run at 65% VO2max. Circulating levels of insulin, glucagon, epinephrine, norepinephrine, growth hormone, testosterone, and cortisol were measured. Plasma substrates included glucose, lactate, free fatty acids, and select amino acids. Except for insulin and cortisol, hormones increased with exercise. While post-exercise insulin concentrations declined similarly in all 3 trials, the glucagon increase was greatest following MILK consumption. CHO blunted the post-exercise increase in growth hormone compared to levels in MILK. Free fatty acids and plasma amino acids also were responsive to nutritional supplementation with both CHO and MILK attenuating the rise in free fatty acids compared to the increase observed in PLA. Correspondingly, respiratory exchange ratio increased during CHO. Essential amino acids increased significantly only after MILK and were either unchanged or decreased in CHO. PLA was characterized by a decrease in branched-chain amino acid concentrations. Modest nutritional supplementation in this study altered the endocrine response as well as substrate availability and utilization following and during an endurance run, respectively.
Authors:
Sharon L Miller; Carl M Maresh; Lawrence E Armstrong; Cara B Ebbeling; Shannon Lennon; Nancy R Rodriguez
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  12     ISSN:  1526-484X     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-25     Completed Date:  2003-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  384-97     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acids / blood
Blood Glucose / metabolism
Dietary Carbohydrates / administration & dosage,  metabolism*
Dietary Proteins / administration & dosage,  metabolism*
Dietary Supplements
Energy Metabolism*
Glucagon / blood
Hormones / blood*
Humans
Insulin / blood
Lactic Acid / blood
Male
Oxygen Consumption
Physical Endurance / physiology*
Respiration
Running*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/Dietary Carbohydrates; 0/Dietary Proteins; 0/Hormones; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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