Document Detail

Metabolic response at repeat PET/CT predicts pathological response to neoadjuvant chemotherapy in oesophageal cancer.
MedLine Citation:
PMID:  22562089     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Reports have suggested that a reduction in tumour 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) examination during or after neoadjuvant chemotherapy may predict pathological response in oesophageal cancer. Our aim was to determine whether metabolic response predicts pathological response to a standardised neoadjuvant chemotherapy regimen within a prospective clinical trial.
METHODS: Consecutive patients staged with potentially curable oesophageal cancer who underwent treatment within a non-randomised clinical trial were included. A standardised chemotherapy regimen (two cycles of oxaliplatin and 5-fluorouracil) was used. PET/CT was performed before chemotherapy and repeated 24-28 days after the start of cycle 2.
RESULTS: Forty-eight subjects were included: mean age 65 years; 37 male. Using the median percentage reduction in SUV(max) (42%) to define metabolic response, pathological response was seen in 71% of metabolic responders (17/24) compared with 33% of non-responders (8/24; P = 0.009, sensitivity 68%, specificity 70%). Pathological response was seen in 81% of subjects with a complete metabolic response (13/16) compared with 38% of those with a less than complete response (12/32; P = 0.0042, sensitivity 52%, specificity 87%). There was no significant histology-based effect.
CONCLUSIONS: There was a significant association between metabolic response and pathological response; however, accuracy in predicting pathological response was relatively low.
R S Gillies; M R Middleton; C Blesing; K Patel; N Warner; R E K Marshall; N D Maynard; K M Bradley; F V Gleeson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-05
Journal Detail:
Title:  European radiology     Volume:  22     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-06     Completed Date:  2013-01-14     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2035-43     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / therapeutic use*
Chemotherapy, Adjuvant
Esophageal Neoplasms / diagnosis,  drug therapy*,  metabolism*
Fluorodeoxyglucose F18 / diagnostic use*,  pharmacokinetics*
Metabolic Clearance Rate
Multimodal Imaging / methods*
Neoadjuvant Therapy / methods
Positron-Emission Tomography*
Radiopharmaceuticals / diagnostic use
Tissue Distribution
Tomography, X-Ray Computed*
Treatment Failure
Treatment Outcome
Grant Support
G9615910//Medical Research Council
Reg. No./Substance:
0/Antineoplastic Agents; 0/Radiopharmaceuticals; 0Z5B2CJX4D/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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