Document Detail

Metabolic recovery after global myocardial ischemia: effects of blood cardioplegic solutions.
MedLine Citation:
PMID:  8665424     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effect of whole blood cardioplegia (WBC) and a mix of crystalloid in blood (CB) hyperkalemic cardioplegic solutions on recovery of the myocardium following global ischemia. DESIGN: Twenty-one dogs were placed on normothermic cardiopulmonary bypass, and a pH probe was inserted in the anterior wall of the left ventricle. Global myocardial ischemia was obtained by clamping the ascending aorta until a decrease in myocardial tissue pH of 0.4 units from baseline value was obtained, at which time cardioplegic solutions were perfused over 30 mins. The aorta was then unclamped and 30 mins of reperfusion was allowed. RESULTS: The aortic cross-clamping time necessary to decrease myocardial tissue pH 0.4 units from baseline averaged 13 +/- 8 mins. Whereas myocardial tissue pH returned to baseline value (6.9 +/- 0.1) after an average of 24 mins with cold (15 degrees C) and warm (35 degrees C) WBC, it took an average of 48 mins to reach control levels when warm CB solutions were used. Moreover, tissue pH decreased temporarily from 6.97 +/- 0.35 to 6.77 +/- 0.37 (P < 0.05) at initiation of normothermic myocardial reperfusion in cold WBC protected animals, and myocardial pH remained normal in the warm WBC group but remained severely acidic in warm CB animals (6.6 +/- 0.3). CONCLUSIONS: Metabolic recovery after global ischemia was faster with WBC cardioplegic protection. Normothermic blood reperfusion in cold WBC protected animals caused a significant but temporary tissue acidosis.
M Carrier; A Khalil; A Tourigny; B C Solymoss; L C Pelletier
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  12     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-05     Completed Date:  1996-08-05     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  607-11     Citation Subset:  IM    
Department of Surgery, Montreal Heart Institute, Quebec.
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MeSH Terms
Blood Gas Analysis
Blood Transfusion / methods*
Disease Models, Animal
Drug Evaluation, Preclinical
Hydrogen-Ion Concentration
Myocardial Ischemia / metabolism*,  therapy*
Myocardial Reperfusion / methods*
Potassium Compounds / therapeutic use*
Regression Analysis
Time Factors
Reg. No./Substance:
0/Potassium Compounds; 0/potassium cardioplegic solution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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