Document Detail

Metabolic programming of long-term outcomes due to fatty acid nutrition in early life.
MedLine Citation:
PMID:  21366871     Owner:  NLM     Status:  In-Data-Review    
Understanding of the importance of dietary fatty acids has grown beyond a simple source of energy to complex roles in regulating gene expression and cell and intracellular communication. This is important because the metabolic and neuroendocrine environment of the fetus and infant plays a key role in guiding the set point of neural receptors that regulate energy homeostasis and expression of genes that control energy storage and oxidation. Early deviations in these pathways have the potential to lead to lasting adaptations, termed metabolic programming, which may combine to increase the risk of metabolic syndrome in later life. The quality of fatty acids in human diets has undergone major changes in the last 50 years, characterized by an increase in ω-6 and decrease in ω-3 fatty acids. Evidence is accumulating to support the concept that the maternal intake of ω-6 and ω-3 fatty acids in gestation and lactation, possibly involving both excess ω-6 and inadequate ω-3 fatty acids, can impact the developing infant tissue lipids and neuroendocrine and metabolic pathways relevant to metabolic programming. Further work is needed to understand the needs for different ω-6 and ω-3 fatty acids during fetal and infant life, and their roles with respect to development of energy homeostasis and metabolism.
Sheila M Innis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Maternal & child nutrition     Volume:  7 Suppl 2     ISSN:  1740-8709     ISO Abbreviation:  Matern Child Nutr     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101201025     Medline TA:  Matern Child Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  112-23     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Departments of Paediatrics and Pathology, Nutrition and Metabolism, Child and Family Research Institute of British Columbia, Vancouver, British Columbia, Canada.
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