| Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy. | |
| | |
MedLine Citation:
|
PMID: 21671558 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Being born small for gestational age (SGA) confers increased risks of perinatal morbidity and mortality and increases the risk of cardiovascular complications and diabetes in later life. Accumulating evidence suggests that the etiology of SGA is usually associated with poor placental vascular development in early pregnancy. We examined metabolomic profiles using ultra performance liquid chromatography-mass spectrometry (UPLC-MS) in three independent studies: (a) venous cord plasma from normal and SGA babies, (b) plasma from a rat model of placental insufficiency and controls and (c) early pregnancy peripheral plasma samples from women who subsequently delivered a SGA baby and controls. Multivariate analysis by cross-validated Partial Least Squares Discriminant Analysis (PLS-DA) of all 3 studies showed a comprehensive and similar disruption of plasma metabolism. A multivariate predictive model combining 19 metabolites produced by a Genetic Algorithm-based search program gave an Odds Ratio for developing SGA of 44, with an area under the Receiver Operator Characteristic curve of 0.9. Sphingolipids, phospholipids, carnitines and fatty acids were among this panel of metabolites. The finding of a consistent discriminatory metabolite signature in early pregnancy plasma preceding the onset of SGA offers insight into disease pathogenesis, and offers the promise of a robust pre-symptomatic screening test. |
| | |
Authors:
|
Richard P Horgan; David I Broadhurst; Sarah K Walsh; Warwick B Dunn; Marie Brown; Claire Roberts; Robyn A North; Lesley M McCowan; Douglas B Kell; Philip N Baker; Louise C Kenny |
Related Documents
:
|
7807488 - Pregnancy after unilateral oophorectomy in a woman with hyperthecosis ovarii. a case re... 20458488 - Polycystic ovarian syndrome and pregnancy outcome. 9130768 - Ovarian pregnancy and operative laparoscopy: report of eight cases. 8059838 - Influence of ovarian endometrioma on fertility. 1290428 - Gestational diabetes in twin pregnancy: prevalence and long-term implications. 8174728 - Epididymal micropuncture with in vitro fertilization and oocyte micromanipulation for t... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-14 |
Journal Detail:
|
Title: Journal of proteome research Volume: - ISSN: 1535-3907 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101128775 Medline TA: J Proteome Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhancing Protease Activity Assay in Droplet-Based Microfluidics Using a Biomolecule Concentrator.
Next Document: Synthesis of hierarchical hollow silica microspheres containing surface nanoparticles employing the ...