| Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients. | |
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MedLine Citation:
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PMID: 16602681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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(1)H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia. |
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Authors:
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Tsz M Tsang; Jeffrey T-J Huang; Elaine Holmes; Sabine Bahn |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of proteome research Volume: 5 ISSN: 1535-3893 ISO Abbreviation: J. Proteome Res. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-10 Completed Date: 2006-05-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101128775 Medline TA: J Proteome Res Country: United States |
Other Details:
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Languages: eng Pagination: 756-60 Citation Subset: IM |
Affiliation:
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Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, SW7 2AZ, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Case-Control Studies Diseases in Twins / metabolism* Female Humans Interviews as Topic Leukapheresis Lipid Metabolism* Lipoproteins, LDL / blood Lipoproteins, VLDL / blood Nuclear Magnetic Resonance, Biomolecular Schizophrenia / genetics, metabolism* Twin Studies as Topic* Twins, Monozygotic / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, LDL; 0/Lipoproteins, VLDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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