Document Detail


Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients.
MedLine Citation:
PMID:  16602681     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
(1)H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8 pairs of age-matched healthy twins in an effort to disentangle genetic and epigenetic components of schizophrenia. We identified alterations in the lipid profile of both affected and unaffected schizophrenia twins. Additionally, there is a close association of VLDL/LDL signals and Global Functioning Scores in female twins suffering from schizophrenia. Our results further support a link between metabolic disturbances and the etiopathology of schizophrenia.
Authors:
Tsz M Tsang; Jeffrey T-J Huang; Elaine Holmes; Sabine Bahn
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of proteome research     Volume:  5     ISSN:  1535-3893     ISO Abbreviation:  J. Proteome Res.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-05-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101128775     Medline TA:  J Proteome Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  756-60     Citation Subset:  IM    
Affiliation:
Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, SW7 2AZ, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Case-Control Studies
Diseases in Twins / metabolism*
Female
Humans
Interviews as Topic
Leukapheresis
Lipid Metabolism*
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Nuclear Magnetic Resonance, Biomolecular
Schizophrenia / genetics,  metabolism*
Twin Studies as Topic*
Twins, Monozygotic / metabolism*
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL; 0/Lipoproteins, VLDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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