| Metabolic profile and sex hormone binding globulin (SHBG) in different reproductive phases of Czech women and their relations to weight, body composition and fat distribution. | |
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MedLine Citation:
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PMID: 19627173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In our study, 213 healthy Czech women aged 20 to 65 years were examined and divided into fully reproductive, premenopausal, menopausal and postmenopausal groups. In all subjects body composition was determined by classical anthropometry and metabolic profile was assessed. A total of 146 subjects completed 3-year longitudinal study. Total and LDL cholesterol increased and ratio HDL/total cholesterol decreased with age (p<0.001), most significantly in menopause. Triacylglycerols increased only up to menopause. HDL had a very slight trend to decrease in menopause and postmenopause. Fasting blood glucose level increased progressively (p<0.001), in postmenopause frequently exceeded normal range. Higher BMI, total fat mass and central fat indices were associated with higher total and LDL cholesterol, triacylglycerols, C-peptide, insulin and fasting blood glucose level (p<0.001; fasting blood glucose level to waist-to-hip ratio: p<0.01) and lower HDL cholesterol (p<0.001). Higher C-peptide and insulin were associated with lower HDL cholesterol and higher triacylglycerols (p<0.001). Fasting glucose correlated with LDL cholesterol (p<0.01). Higher SHBG was associated with higher HDL and lower LDL cholesterol (p<0.001). Hormone replacement treatment was related to lower fasting blood glucose level in postmenopausal women (p<0.01). Oral contraception is suggestive of a positive influence on lipid spectrum by increasing the ratio HDL/total cholesterol. Markers of lipid and carbohydrate metabolism are not only age-related, but they are also related to BMI, total fat mass and central fat indices. Therefore, preventive programs should be focused above all on menopausal women. |
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Authors:
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I KOSKOVA; R PETRASEK; K VONDRA; M DUSKOVA; L STARKA |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 58 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2009 |
Date Detail:
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Created Date: 2009-07-24 Completed Date: 2009-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 393-402 Citation Subset: IM |
Affiliation:
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Faculty of Science, Charles University, Prague, Czech Republic. irenako@quick.cz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity* Adult Aged Biological Markers / blood Blood Glucose / metabolism Body Composition* Body Weight* Contraceptives, Oral / therapeutic use Czech Republic Energy Metabolism* Female Hormone Replacement Therapy Humans Insulin / blood Lipids / blood Longitudinal Studies Menopause / blood* Middle Aged Postmenopause / blood* Premenopause / blood* Sex Hormone-Binding Globulin / analysis* Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Contraceptives, Oral; 0/Lipids; 0/Sex Hormone-Binding Globulin; 11061-68-0/Insulin |
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