| Metabolic profile of glycosaminoglycans in bladder and urethra of female rats during and after pregnancy. | |
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MedLine Citation:
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PMID: 19798458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION AND HYPOTHESIS: The objective of this study is to evaluate pregnancy's action on glycosaminoglycans (GAGs) profile in bladder and urethra of female adult rats. METHODS: Twenty adult female rats were divided into four groups: control, day 10 pregnancy, day 20 pregnancy, and day 5 after delivery. Sulfated GAGs content were determined by densitometry. Hyaluronic acid was assessed by fluorimetric enzyme-linked immunosorbent serologic-like assay. Radioactive GAGs were quantified by measuring radioactivity in electrophoresis gel. Statistical analysis was performed using Kruskal-Wallis and Mann-Whitney tests. RESULTS: In all groups, dermatan sulfate was predominant followed by heparan sulfate and hyaluronic acid. Significant decrease in total GAGs in bladder was observed at the beginning of pregnancy, with progressive increase. Biosynthesis of such molecules showed a similar behavior. In urethra, changes in GAGs content were restricted to the end of pregnancy. Hyaluronic acid content showed a significant increase in bladder during puerperium. CONCLUSIONS: We observed different composition in vesical and urethral tissues during pregnancy and in puerperium. |
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Authors:
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Presciliana Mitrano; Marie Doki Nogueira; Paulo Cezar Feldner; Rodrigo Aquino Castro; Marair Gracio Ferreira Sartori; Helena B Nader; Manoel João Batista Castello Girão |
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Publication Detail:
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Type: Journal Article Date: 2009-10-02 |
Journal Detail:
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Title: International urogynecology journal Volume: 21 ISSN: 1433-3023 ISO Abbreviation: Int Urogynecol J Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-20 Completed Date: 2010-03-31 Revised Date: 2011-08-18 |
Medline Journal Info:
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Nlm Unique ID: 101567041 Medline TA: Int Urogynecol J Country: England |
Other Details:
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Languages: eng Pagination: 241-6 Citation Subset: IM |
Affiliation:
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Section of Urogynecology and Pelvic Surgery, Department of Gynecology, Federal University of São Paulo, Rua dos Otonis, 601 Vila Clementino, 04025-001, São Paulo, SP, Brazil. prescilianag@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Glycosaminoglycans / metabolism* Pregnancy Pregnancy, Animal / metabolism* Rats Rats, Wistar Urethra / metabolism* Urinary Bladder / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Glycosaminoglycans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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