| Metabolic precursors of surfactant disaturated-phosphatidylcholine in preterms with respiratory distress. | |
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MedLine Citation:
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PMID: 19474458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our objective was to study the metabolic precursors of surfactant disaturated-phosphatidylcholine (DSPC) in preterm infants with respiratory distress syndrome (RDS) on mechanical ventilation. We performed 46 DSPC kinetic studies in 23 preterms on fat-free parenteral nutrition and mechanical ventilation (birth weight = 1167 +/- 451 g, gestational age = 28.5 +/- 2.0 weeks). Eight infants received a simultaneous intravenous infusion of U(13)C-glucose and [16,16,16](2)H-palmitate, eight infants received U(13)C-glucose and (2)H(2)O, and seven received U(13)C-palmitate and (2)H(2)O. Surfactant DSPC kinetics were calculated from the isotopic enrichments of DSPC-palmitate from sequential tracheal aspirates and its metabolic precursors in plasma or urine. DSPC fractional synthesis rate (FSR) was 17 +/- 11, 21 +/- 16, and 15 +/- 6%/day from glucose, palmitate, and body water, respectively (P = 0.36). DSPC-FSR from U(13)C-glucose and (2)H(2)O were significantly correlated and yielded similar estimates (difference of -0.1 +/- 3%) (P = 0.91). The difference in the 15 infants receiving palmitate versus (2)H(2)O or palmitate versus glucose was +6.0 +/- 12%/day (P = 0.21). There was a significant correlation between DSPC-FSRs from plasma glucose and plasma FFA. The contribution of glucose versus palmitate to DSPC-FSR was 49 +/- 20% versus 51 +/- 20%, respectively. Plasma glucose and FFA showed similar contributions to DSPC-FSR in infants with RDS and fat-free parenteral nutrition. FSRs from (2)H(2)O or glucose were highly correlated. |
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Authors:
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Paola E Cogo; Carlo Ori; Manuela Simonato; Giovanna Verlato; Ilena Isak; Aaron Hamvas; Virgilio P Carnielli |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-05-27 |
Journal Detail:
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Title: Journal of lipid research Volume: 50 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-03-16 Revised Date: 2010-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
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Languages: eng Pagination: 2324-31 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Padova, Padova, Italy. cogo@pediatria.unipd.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Blood Glucose / metabolism Carbon Isotopes Chromatography, Gas Deuterium Gestational Age Glucose / administration & dosage Humans Infant, Newborn Infant, Premature Infusions, Intravenous Kinetics Mass Spectrometry Palmitates / administration & dosage, blood, urine Phosphatidylcholines / metabolism* Pulmonary Surfactants / metabolism* Respiration, Artificial Respiratory Distress Syndrome, Newborn / metabolism*, therapy Time Factors Water / administration & dosage, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Carbon Isotopes; 0/Palmitates; 0/Phosphatidylcholines; 0/Pulmonary Surfactants; 0/lecithins, disaturated; 50-99-7/Glucose; 7732-18-5/Water; 7782-39-0/Deuterium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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