Document Detail

Metabolic precursors of surfactant disaturated-phosphatidylcholine in preterms with respiratory distress.
MedLine Citation:
PMID:  19474458     Owner:  NLM     Status:  MEDLINE    
Our objective was to study the metabolic precursors of surfactant disaturated-phosphatidylcholine (DSPC) in preterm infants with respiratory distress syndrome (RDS) on mechanical ventilation. We performed 46 DSPC kinetic studies in 23 preterms on fat-free parenteral nutrition and mechanical ventilation (birth weight = 1167 +/- 451 g, gestational age = 28.5 +/- 2.0 weeks). Eight infants received a simultaneous intravenous infusion of U(13)C-glucose and [16,16,16](2)H-palmitate, eight infants received U(13)C-glucose and (2)H(2)O, and seven received U(13)C-palmitate and (2)H(2)O. Surfactant DSPC kinetics were calculated from the isotopic enrichments of DSPC-palmitate from sequential tracheal aspirates and its metabolic precursors in plasma or urine. DSPC fractional synthesis rate (FSR) was 17 +/- 11, 21 +/- 16, and 15 +/- 6%/day from glucose, palmitate, and body water, respectively (P = 0.36). DSPC-FSR from U(13)C-glucose and (2)H(2)O were significantly correlated and yielded similar estimates (difference of -0.1 +/- 3%) (P = 0.91). The difference in the 15 infants receiving palmitate versus (2)H(2)O or palmitate versus glucose was +6.0 +/- 12%/day (P = 0.21). There was a significant correlation between DSPC-FSRs from plasma glucose and plasma FFA. The contribution of glucose versus palmitate to DSPC-FSR was 49 +/- 20% versus 51 +/- 20%, respectively. Plasma glucose and FFA showed similar contributions to DSPC-FSR in infants with RDS and fat-free parenteral nutrition. FSRs from (2)H(2)O or glucose were highly correlated.
Paola E Cogo; Carlo Ori; Manuela Simonato; Giovanna Verlato; Ilena Isak; Aaron Hamvas; Virgilio P Carnielli
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-05-27
Journal Detail:
Title:  Journal of lipid research     Volume:  50     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-03-16     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2324-31     Citation Subset:  IM    
Department of Pediatrics, University of Padova, Padova, Italy.
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MeSH Terms
Analysis of Variance
Blood Glucose / metabolism
Carbon Isotopes
Chromatography, Gas
Gestational Age
Glucose / administration & dosage
Infant, Newborn
Infant, Premature
Infusions, Intravenous
Mass Spectrometry
Palmitates / administration & dosage,  blood,  urine
Phosphatidylcholines / metabolism*
Pulmonary Surfactants / metabolism*
Respiration, Artificial
Respiratory Distress Syndrome, Newborn / metabolism*,  therapy
Time Factors
Water / administration & dosage,  metabolism
Reg. No./Substance:
0/Blood Glucose; 0/Carbon Isotopes; 0/Palmitates; 0/Phosphatidylcholines; 0/Pulmonary Surfactants; 0/lecithins, disaturated; 50-99-7/Glucose; 7732-18-5/Water; 7782-39-0/Deuterium

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