Document Detail


Metabolic plasticity and hematopoietic stem cell biology.
MedLine Citation:
PMID:  23615055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Hematopoietic stem cells (HSCs) residing in the hypoxic niches can both self-renew and give rise to progeny. Multiple regulatory mechanisms for these cellular processes have been identified. Emerging evidence has revealed that metabolism and bioenergetics play important roles in determining stem cell fate in concert with other regulatory networks. In this review, we will discuss recent advances in this field.
RECENT FINDINGS: Recent studies have helped define and redefine metabolic regulation of HSCs. Resting quiescent stem cells use primarily anaerobic glycolysis for energy production and this metabolic program is required to maintain a functional quiescent state. However, when they exit this state and rapidly proliferate and differentiate into different blood cell types, a robust up-regulation of energy metabolism is expected to meet the quickly rising energy demand. Dysregulation of metabolism in HSCs results in various blood disorders, including leukemia.
SUMMARY: Energy metabolism and HSC activity influence and interlink each other in a highly sophisticated and orchestrated manner. Understanding metabolic regulation of HSC function has significant implications for HSC-based therapies and leukemogenesis research.
Authors:
Peter Hsu; Cheng-Kui Qu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in hematology     Volume:  20     ISSN:  1531-7048     ISO Abbreviation:  Curr. Opin. Hematol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-06     Completed Date:  2013-10-23     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  9430802     Medline TA:  Curr Opin Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Differentiation / physiology
Cell Proliferation
Energy Metabolism / physiology*
Hematopoietic Stem Cells / physiology*
Humans
Signal Transduction / physiology
Grant Support
ID/Acronym/Agency:
DK092722/DK/NIDDK NIH HHS; HL068212/HL/NHLBI NIH HHS; R01 DK092722/DK/NIDDK NIH HHS; R01 HL068212/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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