Document Detail

Metabolic and osmoregulatory function at low and high (3800 m) altitude.
MedLine Citation:
PMID:  12405748     Owner:  NLM     Status:  MEDLINE    
Altitude evokes physiological adjustments that include not only respiratory and cardiovascular properties, but also metabolic function, renal and endocrine responses. The purpose of the present study was designed to expand our understanding of the physiological process involved with acclimatisation to high altitude in equids. The study examined temporal effects on metabolic and osmoregulatory function in horses (n = 6) at rest and postexercise at 3800 m. Animals were studied at 225 m (Pb = 743 mmHg) and during a 10 day stay at altitude (Pb = 487 mmHg). Rest samples were taken 90 min postprandial at 0830 h and immediately after the gallop phase of a standard exercise test. Changes in glucose, insulin, cortisol, thyroxine, sodium, potassium, chloride and total protein were assessed at both altitudes. Exercise stimulated increases in cortisol, thyroxine, potassium, and chloride; while the concentrations of glucose, insulin, sodium and total protein (regardless of altitude) decreased. Acute (Day 2) altitude exposure (following transport stress) produced significant increases in glucose, cortisol, thyroxine, chloride and protein at rest and exercise. All variables (except cortisol) appeared to stabilise by Day 4 of altitude exposure. Observations from these data (coupled with haematological and blood gases data) indicate that equids acutely acclimate within 2-3 days to this altitude.
H M Greene; E A Cogger; T L Miltenberger; A K Koch; R E Bray; S J Wickler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-30     Completed Date:  2003-02-26     Revised Date:  2007-05-18    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  545-50     Citation Subset:  IM    
The University of California, White Mountain Research Station, Bishop 93514, USA.
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MeSH Terms
Acclimatization / physiology*
Blood Glucose / analysis
Blood Proteins / analysis
Chlorides / blood
Exercise Test / veterinary
Horses / blood,  physiology*
Hydrocortisone / blood
Insulin / blood
Physical Conditioning, Animal / physiology*
Postprandial Period
Potassium / blood
Sodium / blood
Thyroxine / blood
Water-Electrolyte Balance / physiology*
Reg. No./Substance:
0/Blood Glucose; 0/Blood Proteins; 0/Chlorides; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; 7440-09-7/Potassium; 7440-23-5/Sodium; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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