Document Detail

Metabolic, nutritional, iatrogenic, and artifactual sources of urinary organic acids: a comprehensive table.
MedLine Citation:
PMID:  11978597     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The determination of organic acids and glycine conjugates in urine is key for the diagnosis and follow-up of several inborn errors of metabolism (IEM). However, clinical interpretations may still be hindered by ambiguity in the sources of some urinary organic acids and acylglycines as well as in the relationship between their excretion and IEM. APPROACH: Relevant data have been compiled from major books and references on the topic and by exhaustive bibliographic searches through the Medline and Current Contents databases. CONTENT: A comprehensive table has been designed according to organic acids and conjugates. This table is intended to assist in the interpretation of organic acid profiles because, in addition to IEM, it also refers to other pathologic causes and to physiologic, nutritional, iatrogenic, and artifactual sources. Some preanalytical issues, including possible misinterpretations, are reviewed with regard to IEM.
Alain Kumps; Pierre Duez; Yves Mardens
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  48     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-29     Completed Date:  2002-05-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  708-17     Citation Subset:  IM    
Laboratoire de Biochimie Médicale, Institut de Pharmacie, Université Libre de Bruxelles (ULB), Campus Plaine CP 205/3, Boulevard du Triomphe, B-1050 Brussels, Belgium.
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MeSH Terms
Blood Specimen Collection
Carboxylic Acids / urine*
Glycine / metabolism
Iatrogenic Disease*
Metabolism, Inborn Errors / diagnosis*
Nutritional Physiological Phenomena*
Reg. No./Substance:
0/Carboxylic Acids; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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