Document Detail

Metabolic and neurologic sequelae in a patient with long-standing anorexia nervosa who presented with septic shock and deep hypoglycemia.
MedLine Citation:
PMID:  22072414     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To report the case of a 48-year female with chronic remitting anorexia nervosa who was found comatose at home and admitted to our hospital with a deep hypoglycemia (glucose level 0.6 mmol/L; 11 mg/dL) and septic shock secondary to a bilateral pneumonia.
METHOD: Case report.
RESULTS: After admission to the critical care unit, she further displayed a number of pronounced complications known to be associated with anorexia, including hypophosphatemia, disturbed liver functions and depression of all three hematological cell lines. The neurological recovery of the patient was complicated by encephalopathy and transient tetraparesis. With initial deep hypoglycemia at presentation and persisting coma, magnetic resonance imaging performed 5 days later did not demonstrate characteristic post-hypoglycemic abnormalities. Neuroradiological examination did however reveal the presence of extensive calcifications in the basal ganglia known as Fahr's syndrome.
DISCUSSION: The potential relation between anorexia nervosa and Fahr syndrome has not been described before. The fact that this patient survived a glucose level that is usually associated with a very poor outcome is probably related to its special origin. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2010).
Corine M de Jager; Miriam Hoekstra; Maarten W N Nijsten; Annemieke Oude Lansink; Farouq Ismael
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Publication Detail:
Type:  Journal Article     Date:  2010-11-05
Journal Detail:
Title:  The International journal of eating disorders     Volume:  44     ISSN:  1098-108X     ISO Abbreviation:  Int J Eat Disord     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8111226     Medline TA:  Int J Eat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  756-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Department of Critical Care, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, the Netherlands.
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