Document Detail


Metabolic modulation of myocardial ischemia.
MedLine Citation:
PMID:  16524539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolic pathways of the heart during normoxia and ischemia have been well studied. High plasma fatty acid concentrations and the myocardial accumulation of long-chain fatty acyl metabolites during ischemia correlate with increased morbidity and mortality. However, enhanced glucose use can maintain cell homeostasis, diminish ischemic injury, and be clinically beneficial. Metabolic modulators represent a new class of drugs with the potential to treat myocardial ischemia. They are ideal as adjunctive anti-ischemic therapy because they lack the hemodynamic consequences of traditional therapy and treat the underlying metabolic dysfunction that leads to contractile failure and arrhythmias. Clinical studies have demonstrated their efficacy in acute and chronic settings. It is anticipated that there will be greater utilization of this new class of agents in the near future.
Authors:
Sonal Jani; Steven R Bergmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  8     ISSN:  1523-3782     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-09     Completed Date:  2007-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-30     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Beth Israel Medical Center, Baird 5, 16th Street and First Avenue, New York, NY 10003, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology,  therapeutic use
Enzyme Inhibitors / pharmacology,  therapeutic use
Fatty Acids / metabolism
Glucose / metabolism,  pharmacology,  therapeutic use
Humans
Insulin / pharmacology,  therapeutic use
Lactates / metabolism
Myocardial Ischemia / drug therapy,  metabolism*
Myocardium / metabolism*,  pathology
Oxidation-Reduction
Potassium / pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Enzyme Inhibitors; 0/Fatty Acids; 0/Lactates; 0/glucose-insulin-potassium cardioplegic solution; 11061-68-0/Insulin; 50-99-7/Glucose; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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