Document Detail

Metabolic interactions between essential and trans-fatty acids.
MedLine Citation:
PMID:  8925188     Owner:  NLM     Status:  MEDLINE    
Trans-fatty acids exacerbate essential fatty acid deficiency in experimental animals by interfering with the metabolism of linoleic (18:2n-6) and alpha-linolenic (18:3n-3) acids and, hence, the eicosanoid production. The interfering effect depends on the type of trans-fatty acid. The detrimental effect of trans-fatty acid, however, apparently disappears when dietary linoleic acid is sufficiently supplemented. Trans-fatty acids appear to disturb fetal growth and birth weight, possibly by the same mechanism.
M Sugano; I Ikeda
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in lipidology     Volume:  7     ISSN:  0957-9672     ISO Abbreviation:  Curr. Opin. Lipidol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-11-20     Completed Date:  1996-11-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9010000     Medline TA:  Curr Opin Lipidol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  38-42     Citation Subset:  IM    
Laboratory of Food Science, Kyushu University School of Agriculture, Fukuoka, Japan.
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MeSH Terms
Animals, Newborn
Eicosanoids / biosynthesis
Fatty Acids, Essential / metabolism*
Fatty Acids, Unsaturated / metabolism*
Infant, Newborn
Linoleic Acid
Linoleic Acids / metabolism
Phospholipids / biosynthesis
alpha-Linolenic Acid / metabolism
Reg. No./Substance:
0/Eicosanoids; 0/Fatty Acids, Essential; 0/Fatty Acids, Unsaturated; 0/Linoleic Acids; 0/Phospholipids; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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