Document Detail


Metabolic interactions between acetylsalicylic acid and benzene.
MedLine Citation:
PMID:  12767688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to evaluate cytochrome P-450 dependent hepatic monooxygenases system and urinary excretions of phenol and muconic acid in animals subjected to acetylsalicylic acid (ASA) orally and benzene by inhalations. ASA increased urinary excretion of muconic acid although it did not affect the urinary level of phenol. Benzene decreased concentrations of P-450 and b(5) cytochromes and the activities of NADPH-cytochrome P-450 and NADH-cytochrome b(5) reductases. In rats exposed to ASA and benzene simultaneously the concentration of both cytochromes and the activity of the cytochrome dependent reductases was higher than in the rats exposed only to benzene and sometimes exceeded the control group values.
Authors:
Joanna Kowalówka-Zawieja; Barbara Zielińska-Psuja; Andrzej Plewka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  188     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-27     Completed Date:  2003-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  161-70     Citation Subset:  IM    
Affiliation:
Department of Toxicology, University of Medical Sciences, Dojazd 30 Poznań, Poland. jzawieja@am.poznan.pl
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Animals
Anti-Inflammatory Agents, Non-Steroidal / metabolism*,  toxicity
Aspirin / metabolism*,  toxicity
Benzene / administration & dosage,  metabolism*,  toxicity
Cytochrome P-450 Enzyme System / metabolism*
Cytochrome Reductases
Cytochrome-B(5) Reductase
Cytochromes b5 / metabolism
Drug Interactions
Male
NADPH-Ferrihemoprotein Reductase / metabolism
Phenol / urine
Rats
Rats, Wistar
Sorbic Acid / analogs & derivatives*,  metabolism
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 108-95-2/Phenol; 110-44-1/Sorbic Acid; 50-78-2/Aspirin; 505-70-4/muconic acid; 71-43-2/Benzene; 9035-39-6/Cytochromes b5; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.6.2.-/Cytochrome Reductases; EC 1.6.2.2/Cytochrome-B(5) Reductase; EC 1.6.2.4/NADPH-Ferrihemoprotein Reductase

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