Document Detail


Metabolic and hormonal derangements in pulmonary hypertension: from mouse to man.
MedLine Citation:
PMID:  20939841     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary arterial hypertension (PAH) is a complex disease with significant morbidity and mortality. Recent animal and human studies have highlighted abnormalities in regulation and metabolism of insulin, sex hormones, adipokines and lipids that may play a role in disease development. Mouse studies suggest features of the metabolic syndrome (MS) including insulin resistance, deficiencies in peroxisome proliferator-activated receptor γ and apolipoprotein E, and low adiponectin are linked to development of PAH. In humans, insulin resistance, the MS and low levels of high-density lipoprotein have been associated with PAH. In addition, abnormal metabolism of oestrogens has been demonstrated in human and animal models of PAH, suggesting an important relationship of sex hormones and pulmonary vascular disease. Improved understanding of how metabolic and hormonal derangements relate to development and progression of pulmonary hypertension may lead to better disease therapies and understanding of potential risk factors. This review will focus on the animal and human data regarding metabolic and sex hormone derangements in PAH.
Authors:
M E Pugh; A R Hemnes
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International journal of clinical practice. Supplement     Volume:  -     ISSN:  1368-504X     ISO Abbreviation:  Int J Clin Pract Suppl     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-13     Completed Date:  2011-02-03     Revised Date:  2013-09-24    
Medline Journal Info:
Nlm Unique ID:  9712380     Medline TA:  Int J Clin Pract Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  5-13     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Vanderbilt University Medical Center, Nashville, TN 37232, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipokines / physiology
Animals
Dyslipidemias / physiopathology
Gonadal Steroid Hormones / blood
Humans
Hypertension, Pulmonary / blood,  physiopathology*
Insulin Resistance / physiology
Metabolic Syndrome X / diagnosis,  physiopathology
Mice
Sex Factors
Grant Support
ID/Acronym/Agency:
1UL1 RR024975/RR/NCRR NIH HHS; 5 KO8 HL093363-3/HL/NHLBI NIH HHS; K08 HL093363/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adipokines; 0/Gonadal Steroid Hormones
Comments/Corrections

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