| Metabolic and hormonal derangements in pulmonary hypertension: from mouse to man. | |
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MedLine Citation:
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PMID: 20939841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary arterial hypertension (PAH) is a complex disease with significant morbidity and mortality. Recent animal and human studies have highlighted abnormalities in regulation and metabolism of insulin, sex hormones, adipokines and lipids that may play a role in disease development. Mouse studies suggest features of the metabolic syndrome (MS) including insulin resistance, deficiencies in peroxisome proliferator-activated receptor γ and apolipoprotein E, and low adiponectin are linked to development of PAH. In humans, insulin resistance, the MS and low levels of high-density lipoprotein have been associated with PAH. In addition, abnormal metabolism of oestrogens has been demonstrated in human and animal models of PAH, suggesting an important relationship of sex hormones and pulmonary vascular disease. Improved understanding of how metabolic and hormonal derangements relate to development and progression of pulmonary hypertension may lead to better disease therapies and understanding of potential risk factors. This review will focus on the animal and human data regarding metabolic and sex hormone derangements in PAH. |
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Authors:
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M E Pugh; A R Hemnes |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: International journal of clinical practice. Supplement Volume: - ISSN: 1368-504X ISO Abbreviation: Int J Clin Pract Suppl Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-13 Completed Date: 2011-02-03 Revised Date: 2011-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9712380 Medline TA: Int J Clin Pract Suppl Country: England |
Other Details:
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Languages: eng Pagination: 5-13 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Vanderbilt University Medical Center, Nashville, TN 37232, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipokines
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physiology Animals Dyslipidemias / physiopathology Gonadal Steroid Hormones / blood Humans Hypertension, Pulmonary / blood, physiopathology* Insulin Resistance / physiology Metabolic Syndrome X / diagnosis, physiopathology Mice Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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1UL1 RR024975/RR/NCRR NIH HHS; 5 KO8 HL093363-3/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adipokines; 0/Gonadal Steroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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