| Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man. | |
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MedLine Citation:
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PMID: 9352380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The time course of the effects of intravenous or intracoronary administration of peptide leukotrienes on metabolic parameters and on systemic and coronary hemodynamics was evaluated in 15 patients with normal coronary arteries. Peptide leukotriene C4 (2 nmol given as a bolus intravenous injection) induced an early fall (at 2 min) in mean arterial pressure (P < 0.02) associated with a rise in heart rate (P < 0.001) and in plasma levels of epinephrine (P < 0.05) and norepinephrine (P < 0.005), but without significant changes in coronary blood flow or coronary vascular resistance. Mean arterial pressure, heart rate, norepinephrine, and epinephrine returned to baseline values 10 min after leukotriene C4 administration. In contrast, at 10 min post leukotriene C4, with coronary blood flow and myocardial oxygen consumption unchanged, an increase in coronary vascular resistance (P < 0.05) and in myocardial oxygen extraction (P < 0.01) was observed, which returned to baseline values at 20 min post leukotriene C4. Peptide leukotriene D4 (3 nmol, given in the left coronary artery) induced an early (20 s) and transient fall in mean arterial pressure (P < 0.001) paralleled by a rise in heart rate and plasma levels of epinephrine and norepinephrine, all of which returned to baseline at 10 min. Coronary vascular resistance increased at 10 and 15 min (P < 0.02 and P < 0.05, respectively) and myocardial oxygen extraction at 15 min (P < 0.02). These results suggest that small doses of peptide leukotrienes induce both an early and transient fall in mean arterial pressure associated with secondary sympathoadrenergic activation, and a late increase in small coronary arteriolar resistance. |
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Authors:
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C Vigorito; A Giordano; R Cirillo; A Genovese; F Rengo; G Marone |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical & laboratory research Volume: 27 ISSN: 0940-5437 ISO Abbreviation: Int. J. Clin. Lab. Res. Publication Date: 1997 |
Date Detail:
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Created Date: 1998-01-06 Completed Date: 1998-01-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9206491 Medline TA: Int J Clin Lab Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 178-84 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Naples Federico II, School of Medicine, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Coronary Circulation / drug effects Epinephrine / blood Female Heart / drug effects Heart Rate / drug effects Hemodynamics / drug effects* Humans Injections, Intravenous Leukotriene C4 / administration & dosage, pharmacology* Leukotriene D4 / administration & dosage, pharmacology* Male Middle Aged Norepinephrine / blood Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine; 72025-60-6/Leukotriene C4; 73836-78-9/Leukotriene D4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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