| Metabolic and hemodynamic effects of nicardipine during pacing-induced angina pectoris. | |
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MedLine Citation:
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PMID: 3812268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During repeat exercise testing in 10 patients with stable angina, individual optimal doses of nicardipine were determined. Hemodynamic values and cardiac metabolism were studied during 2 pacing periods carried out before and after this dose (mean 5.3 mg). Postpacing ST-segment depression diminished (1 mm) after nicardipine administration (p less than 0.05), whereas pacing time to onset of angina did not change. Nicardipine administration increased heart rate 16% (p less than 0.005) and reduced systolic (10%) and diastolic (8%) blood pressures (both p less than 0.005). Coronary blood flow increased 16% (p less than 0.05) and coronary vascular resistance decreased 24% (p less than 0.01). Myocardial oxygen consumption was unchanged despite an 11% decrease in rate-pressure product during pacing (p less than 0.02). In the control state before nicardipine administration, metabolic signs of ischemia included release of lactate across the heart in 7 patients, decreased mean free fatty acid and glutamate uptake and alanine release during pacing, together with increased glucose uptake and citrate release during recovery. After nicardipine lactate release decreased in 5 of the 7 patients, pacing no longer changed free fatty acid, glutamate and alanine uptake/release from the level at rest. During recovery glucose uptake was reduced and citrate release was unaffected. The hemodynamic data indicate that nicardipine is a systemic and coronary vasodilator, increasing oxygen supply to the ischemic myocardium. The metabolic results indicate a change in substrate utilization toward that of normal heart, suggesting improved aerobic energy supply. |
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Authors:
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A Thomassen; J P Bagger; T T Nielsen; P Henningsen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 59 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-16 Completed Date: 1987-03-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 219-24 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine
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metabolism Angina Pectoris / drug therapy, metabolism*, physiopathology* Blood Pressure / drug effects Cardiac Pacing, Artificial Citrates / metabolism Coronary Circulation / drug effects Fatty Acids, Nonesterified / metabolism Female Glucose / metabolism Glutamates / metabolism Heart Catheterization Heart Rate / drug effects Hemodynamics / drug effects* Humans Lactates / metabolism Male Middle Aged Myocardium / metabolism* Nicardipine / pharmacology* Oxygen Consumption / drug effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Citrates; 0/Fatty Acids, Nonesterified; 0/Glutamates; 0/Lactates; 50-99-7/Glucose; 55985-32-5/Nicardipine; 56-41-7/Alanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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