Document Detail

Metabolic and haemodynamic changes in the heart during the early phase of cardiopulmonary bypass: I. Clinical observations.
MedLine Citation:
PMID:  2590918     Owner:  NLM     Status:  MEDLINE    
Knowledge of the effects of cardiopulmonary bypass on the myocardium and on cardiac function is limited. We therefore studied changes in haemodynamics and myocardial metabolism during the initial phase of cardiopulmonary bypass in two patient groups. In one group "normothermia" (34 degrees C) was used while on bypass, with an empty beating heart; in the other group hypothermia (range 27-33 degrees C) with ventricular fibrillation was used. Mean aortic pressure and myocardial oxygen consumption decreased significantly in both groups after instalment of CPB. The arterial-coronary sinus differences in lactate changed to negative values within 5 min of the start of bypass, indicating release instead of uptake of lactate. This release was maintained during the observation period and increased significantly in the hypothermic patient group when the ventricles were fibrillating. Therefore in patients undergoing aorto-coronary bypass surgery, detrimental changes in the myocardium must be anticipated during the initial phase of cardiopulmonary bypass prior to aortic cross clamping.
F H van der Veen; G J van der Vusse; W Flameng; W A Coumans; R S Reneman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  23     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1990-01-24     Completed Date:  1990-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  468-71     Citation Subset:  IM    
Department of Physiology, University of Limburg, Maastricht, The Netherlands.
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MeSH Terms
Aorta / physiology*
Blood Pressure*
Body Temperature
Cardiopulmonary Bypass*
Coronary Artery Bypass*
Lactates / metabolism
Middle Aged
Myocardium / metabolism*
Oxygen Consumption
Reg. No./Substance:

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