| Metabolic and genetic factors contributing to alcohol induced effects and fetal alcohol syndrome. | |
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MedLine Citation:
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PMID: 16908065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alcohol-related damages on newborns and infants include a wide variety of complications from facial anomalies to neurodevelopmental delay, known as fetal alcohol syndrome (FAS). However, only less than 10% of women drinking alcohol during pregnancy have children with FAS. Understanding the risk factors increasing the probability for newborn exposed in utero to alcohol to develop FAS is therefore a key issue. The involvement of genetics as a one risk factor in FAS has been suggested by animal models and by molecular epidemiological studies on different populations, bearing allelic variants for those enzymes, such as ADH e CYP2E1, involved in ethanol metabolism. Indeed, one of the major factors determining the peak blood alcohol exposure to the fetus is the metabolic activity of the mother, in addition to placental and fetal metabolism, explaining, at least partially, the risk of FAS. The different rates of ethanol metabolism may be the result of genetic polymorphisms, the most relevant of which have been described in the paper. |
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Authors:
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Simonetta Gemma; Susanna Vichi; Emanuela Testai |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-09-05 |
Journal Detail:
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Title: Neuroscience and biobehavioral reviews Volume: 31 ISSN: 0149-7634 ISO Abbreviation: Neurosci Biobehav Rev Publication Date: 2007 |
Date Detail:
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Created Date: 2007-01-16 Completed Date: 2007-04-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806090 Medline TA: Neurosci Biobehav Rev Country: United States |
Other Details:
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Languages: eng Pagination: 221-9 Citation Subset: IM |
Affiliation:
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Environment and Primary Prevention Department, Mechanisms of Toxicity Unit, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System Depressants / adverse effects* Ethanol / adverse effects* Female Fetal Alcohol Syndrome / genetics*, metabolism* Humans Male Metabolic Networks and Pathways / drug effects*, genetics* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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