Document Detail

Metabolic fuel selection: the importance of being flexible.
MedLine Citation:
PMID:  15578087     Owner:  NLM     Status:  MEDLINE    
Studies in genetically engineered mice have shown the importance of cross-talk between organs in the regulation of energy metabolism. In this issue, a careful metabolic characterization of mice with genetic deficiency of the GLUT4 glucose transporter in adipocytes and muscle is reported. These mice compensate for decreased peripheral glucose disposal by increasing hepatic glucose uptake and lipid synthesis as well as by increasing lipid utilization in peripheral tissues. These findings are relevant to humans with type 2 diabetes, in whom a key feature is diminished peripheral glucose disposal.
Perry E Bickel
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  114     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-03     Completed Date:  2005-02-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1547-9     Citation Subset:  AIM; IM    
Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, Missouri 63105, USA.
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MeSH Terms
Adipose Tissue / metabolism
Diabetes Mellitus, Type 2 / metabolism
Energy Metabolism*
Glucose / metabolism
Glucose Transporter Type 4
Liver / metabolism
Mice, Knockout
Monosaccharide Transport Proteins / genetics*,  metabolism*
Muscle Proteins / genetics*,  metabolism*
Muscle, Skeletal / metabolism
Reg. No./Substance:
0/Glucose Transporter Type 4; 0/Monosaccharide Transport Proteins; 0/Muscle Proteins; 0/Slc2a4 protein, mouse; 50-99-7/Glucose
Comment On:
J Clin Invest. 2004 Dec;114(11):1666-75   [PMID:  15578099 ]

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