Document Detail


Metabolic fluxes in skeletal muscle in relation to obesity and insulin resistance.
MedLine Citation:
PMID:  16150382     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present article addresses the hypothesis that inefficient skeletal muscle lipid utilization may relate to the development of obesity and insulin resistance. In practice, there is evidence of impaired muscle fatty acid utilization in the obese state, and studies indicate that differences in muscle fatty acid oxidative capacity might play a role in the pathogenesis of obesity. The link between obesity and insulin resistance has been recognized for many years. There is accumulating evidence that a disturbed muscle fat oxidative capacity results in the accumulation of the lipid intermediates diacylglycerol and Fatty acid acyl coenzyme A (CoA), which may interfere with insulin signaling and result in an inhibition of insulin-mediated glucose uptake. Underlying mechanisms for disturbed fatty acid handling may relate to impaired adipose tissue lipolysis, abnormal muscle fatty acid uptake and a reduced ability to oxidize fat. Many of these abnormalities have been reported both in the obese and the type 2 diabetic state. The role of obesity per se in these disturbances is an important question that needs to be addressed.
Authors:
Ellen E Blaak
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  19     ISSN:  1521-690X     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-09     Completed Date:  2005-11-01     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-403     Citation Subset:  IM    
Affiliation:
Department of Human Biology, Nutrition Research Centre, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. e.blaak@hb.unimaas.nl
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Diabetes Mellitus, Type 2 / physiopathology
Fatty Acids, Nonesterified / metabolism
Female
Humans
Insulin Resistance / physiology*
Lipid Metabolism
Male
Mitochondria / physiology
Muscle, Skeletal / metabolism*
Obesity / metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified

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