| Metabolic fate of oleic acid, palmitic acid and stearic acid in cultured hamster hepatocytes. | |
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MedLine Citation:
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PMID: 8670161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Unlike other saturated fatty acids, dietary stearic acid does not appear to raise plasma cholesterol. The reason for this remains to be established, although it appears that it must be related to inherent differences in the metabolism of the fatty acid. In the present study, we have looked at the metabolism of palmitic acid and stearic acid, in comparison with oleic acid, by cultured hamster hepatocytes. Stearic acid was taken up more slowly and was poorly incorporated into both cellular and secreted triacylglycerol. Despite this, stearic acid stimulated the synthesis and secretion of triacylglycerol to the same extent as the other fatty acids. Incorporation into cellular phospholipid was lower for oleic acid than for palmitic acid and stearic acid. Desaturation of stearic acid, to monounsaturated fatty acid, was found to be greater than that of palmitic acid. Oleic acid produced from stearic acid was incorporated into both triacylglycerol and phospholipid, representing 13% and 6% respectively of the total after a 4 h incubation. Significant proportions of all of the fatty acids were oxidized, primarily to form ketone bodies, but by 8 h more oleic acid had been oxidized compared with palmitic acid and stearic acid. |
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Authors:
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J S Bruce; A M Salter |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 316 ( Pt 3) ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-08-07 Completed Date: 1996-08-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 847-52 Citation Subset: IM |
Affiliation:
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Department of Applied Biochemistry and Food Science, University of Nottingham, Loughborough, Leicestershire, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Carbon Radioisotopes Cells, Cultured Cricetinae Fatty Acids, Monounsaturated / metabolism Fatty Acids, Nonesterified / isolation & purification, metabolism Ketone Bodies / metabolism Kinetics Liver / metabolism* Male Mesocricetus Oleic Acid Oleic Acids / metabolism* Oxidation-Reduction Palmitic Acid Palmitic Acids / metabolism* Radioisotope Dilution Technique Stearic Acids / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Nonesterified; 0/Ketone Bodies; 0/Oleic Acids; 0/Palmitic Acids; 0/Stearic Acids; 112-80-1/Oleic Acid; 57-10-3/Palmitic Acid; 57-11-4/stearic acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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