Document Detail

Metabolic fate of non-esterified fatty acids in isolated hepatocytes from newborn and young pigs. Evidence for a limited capacity for oxidation and increased capacity for esterification.
MedLine Citation:
PMID:  6870859     Owner:  NLM     Status:  MEDLINE    
In hepatocytes isolated from 48 h-old starved of suckling newborn pigs or from 15-day-old starved piglets, the rate of ketogenesis from oleate or from octanoate is very low. This is not due to an inappropriate fatty acid uptake by the isolated liver cells, but results from a limited capacity for fatty acid oxidation. Some 80-95% of oleate taken up is converted into esterified fats, whatever the age or the nutritional conditions. Three lines of indirect evidences suggest that fatty acid oxidation is not controlled primarily by malonyl-CoA concentration in newborn pig liver. Firstly, the addition of glucagon does not increase fatty acid oxidation or ketogenesis. Secondly, the rate of lipogenesis is very low in isolated hepatocytes from newborn pigs. Thirdly, the rates of oxidation and ketogenesis from octanoate are also decreased in isolated hepatocytes from newborn and young piglets. The huge rate of esterification of fatty acids in the liver of the newborn pigs probably represents a species-specific difference in intrahepatic fatty acid metabolism.
J P Pégorier; P H Duée; J Girard; J Peret
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  212     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
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MeSH Terms
Age Factors
Animals, Newborn / metabolism*
Fatty Acids, Nonesterified / metabolism*
Glucagon / pharmacology
Ketones / biosynthesis
Liver / cytology,  drug effects,  metabolism*
Oleic Acid
Oleic Acids / metabolism
Starvation / metabolism
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Ketones; 0/Oleic Acids; 112-80-1/Oleic Acid; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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