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Metabolic fate of neutral human milk oligosaccharides in exclusively breastfed infants.
MedLine Citation:
PMID:  25330044     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SCOPE:: Various biological effects have been postulated for human milk oligosaccharides (HMO), as deduced from in vitro, animal, and epidemiological studies. Little is known about their metabolic fate in vivo in the breastfed infant, which is presented here.
METHODS AND RESULTS:: Human milk, infant urine and faeces were collected from ten mother-child pairs and analysed by MALDI-TOF MS(/MS), accompanied by high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD). Previously, we detected intact small and complex HMO in infant urine, which had been absorbed from gut, as verified via intrinsic (13) C-labelling. Our current work reveals the presence of novel HMO metabolites in urine and faeces of breast-fed infants. The novel metabolites were identified as acetylated HMOs and other modified HMOs, produced by the infants or by their gut microbiota. The finding of secretor- or Lewis-specific HMO in the faeces/urine of infants fed with non-secretor or Lewis-negative milk suggested a correspondent modification in the infant.
CONCLUSION:: Our study reveals new insights into the metabolism of neutral HMO in exclusively breastfed infants and provides further indications for multiple factors influencing HMO metabolism and functions which should be considered in future in vivo investigations. This article is protected by copyright. All rights reserved.
Authors:
Viktoria Dotz; Silvia Rudloff; Christina Meyer; Günter Lochnit; Clemens Kunz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-20
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  -     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-20     Completed Date:  -     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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