| Metabolic fate of N-nitrodibutylamine in the rat. | |
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MedLine Citation:
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PMID: 3082813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolic fate of N-nitrodibutylamine (NO2DBA) and N-nitrobutylamine (NO2BA) was investigated in the rat. Eight N-nitramines, including glucuronides, were isolated and identified from urine of rats given NO2DBA. They were produced by omega, omega-1, omega-2 and alpha oxidations of the N-nitramine. The in vivo metabolic pattern of NO2DBA was similar to that of N-nitrosodibutylamine, except that the monodealkylated metabolite NO2BA was also isolated and characterized. When NO2BA was administered to rats, no N-nitramine other than a small amount of unchanged NO2BA was identified in the urine. Besides N-nitramines, N-acetyl-S-(butyl, 3-oxobutyl and 3-hydroxybutyl)-L-cysteines were isolated and identified (as their methyl esters) from the urine of rats given both NO2DBA and NO2BA. The relative ratio of these three L-cysteine derivatives obtained from NO2DBA was quite similar to that from NO2BA, indicating that NO2DBA produces in vivo a chemical species with butylating ability through NO2BA. |
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Authors:
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E Suzuki; M Mochizuki; T Suzuki; M Okada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese journal of cancer research : Gann Volume: 77 ISSN: 0910-5050 ISO Abbreviation: Jpn. J. Cancer Res. Publication Date: 1986 Jan |
Date Detail:
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Created Date: 1986-04-29 Completed Date: 1986-04-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8509412 Medline TA: Jpn J Cancer Res Country: JAPAN |
Other Details:
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Languages: eng Pagination: 39-44 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkylating Agents
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pharmacology Animals Biotransformation Butylamines / metabolism* Male Mutagens / metabolism* Oxidation-Reduction Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Alkylating Agents; 0/Butylamines; 0/Mutagens; 4164-31-2/N-nitrodibutylamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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