Document Detail

Metabolic exercise test data combined with cardiac and kidney indexes, the MECKI score: A multiparametric approach to heart failure prognosis.
MedLine Citation:
PMID:  22795401     Owner:  NLM     Status:  Publisher    
OBJECTIVES: We built and validated a new heart failure (HF) prognostic model which integrates cardiopulmonary exercise test (CPET) parameters with easy-to-obtain clinical, laboratory, and echocardiographic variables. BACKGROUND: HF prognostication is a challenging medical judgment, constrained by a magnitude of uncertainty. METHODS: Our risk model was derived from a cohort of 2716 systolic HF patients followed in 13 Italian centers. Median follow up was 1041days (range 4-5185). Cox proportional hazard regression analysis with stepwise selection of variables was used, followed by cross-validation procedure. The study end-point was a composite of cardiovascular death and urgent heart transplant. RESULTS: Six variables (hemoglobin, Na(+), kidney function by means of MDRD, left ventricle ejection fraction [echocardiography], peak oxygen consumption [% pred] and VE/VCO(2) slope) out of the several evaluated resulted independently related to prognosis. A score was built from Metabolic Exercise Cardiac Kidney Indexes, the MECKI score, which identified the risk of study end-point with AUC values of 0.804 (0.754-0.852) at 1year, 0.789 (0.750-0.828) at 2years, 0.762 (0.726-0.799) at 3years and 0.760 (0.724-0.796) at 4years. CONCLUSIONS: This is the first large-scale multicenter study where a prognostic score, the MECKI score, has been built for systolic HF patients considering CPET data combined with clinical, laboratory and echocardiographic measurements. In the present population, the MECKI score has been successfully validated, performing very high AUC.
Piergiuseppe Agostoni; Ugo Corrà; Gaia Cattadori; Fabrizio Veglia; Rocco La Gioia; Angela B Scardovi; Michele Emdin; Marco Metra; Gianfranco Sinagra; Giuseppe Limongelli; Rossella Raimondo; Federica Re; Marco Guazzi; Romualdo Belardinelli; Gianfranco Parati; Damiano Magrì; Cesare Fiorentini; Alessandro Mezzani; Elisabetta Salvioni; Domenico Scrutinio; Renato Ricci; Luca Bettari; Andrea Di Lenarda; Luigi E Pastormerlo; Giuseppe Pacileo; Raffaella Vaninetti; Anna Apostolo; Annamaria Iorio; Stefania Paolillo; Pietro Palermo; Mauro Contini; Marco Confalonieri; Pantaleo Giannuzzi; Andrea Passantino; Livio Dei Cas; Massimo F Piepoli; Claudio Passino;
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-13
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Centro Cardiologicico Monzino, IRCCS, Milano, Italy; Dipartimento di Scienze Cardiovascolari, Università di Milano, Milano, Italy; Department of Respiratory and Critical Care Medicine, University of Washington, Seattle, WA, United States.
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