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Metabolic engineering to improve 5-aminolevulinic acid production.
MedLine Citation:
PMID:  22008939     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
5-Aminolevulinic acid (ALA) has recently attracted significant attentions due to its potential applications in many diverse fields. The majority of engineered ALA producers are based on the whole cell catalysis, supplemented with succinate and glycine as precursors. Recently, we succeeded in producing ALA directly from inexpensive glucose, through re-constructing the native C5 pathway of ALA synthesis in Escherichia coli. Herein,we further discuss ALA production by manipulating the C5 and C4 pathways in Escherichia coli through the strategy of metabolic engineering.
Authors:
Zhen Kang; Yang Wang; Qiang Wang; Qingsheng Qi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-01
Journal Detail:
Title:  Bioengineered bugs     Volume:  2     ISSN:  1949-1026     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101525147     Medline TA:  Bioeng Bugs     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China.
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