Document Detail

Metabolic engineering of new fatty acids in plants.
MedLine Citation:
PMID:  15753001     Owner:  NLM     Status:  MEDLINE    
Metabolic engineering of plants to express high levels of new fatty acids that are of nutritional and industrial importance has proven to be highly challenging. Significant advances have been made recently, however, particularly in the development of the first plant oils to contain long-chain polyunsaturated fatty acids, such as arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid. Methods of increasing the accumulation of Delta12-modified fatty acids synthesized by transgenically expressed FAD2-like enzymes have also been investigated. Biochemical analyses of plants that express these introduced fatty-acid metabolic pathways have highlighted the central importance of ensuring the removal of novel fatty acids from their site of synthesis on phosphatidylcholine to enable their further modification, exclusion from membrane lipids and accumulation in seed triacylglycerols.
Surinder P Singh; Xue-Rong Zhou; Qing Liu; Sten Stymne; Allan G Green
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in plant biology     Volume:  8     ISSN:  1369-5266     ISO Abbreviation:  Curr. Opin. Plant Biol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-08     Completed Date:  2005-05-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100883395     Medline TA:  Curr Opin Plant Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-203     Citation Subset:  IM    
CSIRO Plant Industry, PO Box 1600, Canberra, ACT 2601, Australia.
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MeSH Terms
Fatty Acids, Nonesterified / metabolism*
Fatty Acids, Unsaturated / genetics,  metabolism*
Genetic Engineering / methods
Plants / genetics,  metabolism*
Plants, Genetically Modified / metabolism
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated

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